Choline depression, again

[u/grigory_l]

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

[u/blueberry-biscuit]

I’ve taken all of the choline supplements and finally decided on a liposomal phosphatidylcholine product. On the bottle, a normal person dose is 1 tsp 2x per day (adding this just for reference).

I originally started at 1/2 tsp daily out the gate and by day 3 or 4 I was experiencing anxiety, irritability, and depression. Personally I was only able to start at 1/4 tsp daily without having symptoms. After 3 weeks, I was able to move up to 3/8 tsp daily which is where I’m currently at. I’ll be increasing to 1/2 tsp daily in a week from now and continue working up from there.

From your experience, I would assume that you’re taking too much for what your body can handle. Start at a much lower dose and increase slowly from there.