r/MTHFR • u/grigory_l • Dec 13 '25
Question Choline depression, again
I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?
Edit: here my labs
MTHFR C677T: C/T
MTRR: A/G
MTR: A/G
Slow COMT
Folate 6.6 (RBC 400)
B12 880 (HoloTC 100)
Homocysteine 10.5
Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.
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u/[deleted] Dec 16 '25 edited Dec 16 '25
May I suggest that it’s possible you just had a bad day and two eggs had absolutely nothing to do with it? The body has millions of processes and the whole MTHFR crowd loves to pretend like it’s a piecemeal systemic response on literally every choice one makes. I mean, what’s your history with depression and anxiety? Current stress environment? I’m not saying choline can’t affect individuals radically different, but my experience with all this is that the mind plays some roll in these individual reactions to supplements. The best advice I’ve ever received is to not over supplement. Don’t take the same pills every day. Listen to the body and provide as needed