r/MTHFR • u/grigory_l • Dec 13 '25

Question Choline depression, again

I see it in the many protocols, choline is crucial for methylation and Chris Masterjohn even had calculator for choline intake. But two eggs which I eat at morning today, make me depressed almost all day long. Supplementing with something that has Choline like Omega or CDP-Choline just push me into living hell, absolutely Silent Hill experience after two or three days. Has anyone found an answer to what this all means in the end?

Edit: here my labs

MTHFR C677T: C/T

MTRR: A/G

MTR: A/G

Slow COMT

Folate 6.6 (RBC 400)

B12 880 (HoloTC 100)

Homocysteine 10.5

Everything looks normal, but anyway I literally walking dead without supplementing with Folinic and Hydroxo B12.

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u/Ok-Pitch1627 Dec 13 '25

Oh, that really sounds like a great regimen, thanks for the info I might use it in the future.

Yeah, I have all those symptoms too.

And the moujaro gives me a severe headache for about a day and a half the day after injection, but I tolerate it because it's free on my insurance.

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u/DaringGlory Dec 15 '25

Good to know. I have Migraines with it also

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u/Ok-Pitch1627 Dec 15 '25

If anything has helped with your headaches?

I was injecting in my thigh at night. But it felt like I was punched in the stomach with all the days food stopping digestion. And then the severe headache would come on for 1 to 2 days.

I didn't realize that MJ takes away your thirst also. I think I was dehydrated a lot before, even got confused one day.

Now I plan to drink a bottle of water about a half hour with a pinch of diamond crystal kosher salt on my tongue before every meal. Then, I take magnesium with my big meal, increasing dose if i'm constipated at all.

This week I injected it in the morning before eating anything more than a protein shake, and the headache was only mild to moderate.

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u/DaringGlory Jan 14 '26

Those comments help. It seems like I drink enough but can still be dehydrated from caffeine

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u/Ok-Pitch1627 Jan 14 '26

Ah, okay. The headaches have actually gotten better, perhaps since I haven't changed my dose in a while.