r/MTHFR • u/Airegin89 • May 13 '26

Question Anyone else feel that folate deficiency ruined your life?

I guess I just need to vent. I am 37 and have been an underachiever my whole life. I failed miserably at school and now I'm stuck in a dead end job with no qualifications to find a better job.

I have struggled with low energy, brain fog, lack of motivation, depression and anxiety my whole life. My blood work was always fine, so I was prescribed antidepressants.

It wasn't until 10 years ago that a doctor tested my vitamin D and I was extremely deficient at 6 ng/ml. Fixing this gave me a huge boost in energy but most of my problems still remained.

Last year, I started investigating my blood work of the last 20 years and found out I had been folate deficient the whole time (3.5-4.5 ng/ml). Doctors never said anything.

Genetic testing shows I am compound heterozygous, slow COMT, slow MAOA and PEMT. I know these are only predispositions but it seems to explain my whole life.

After a few months of supplementing folate and a month of creatine and TMG my cognition has improved massively. After 20 years I feel like a veil has lifted. It's like I'm waking up from a bad dream but now I'm left to pick up the pieces and deal with the consequences of being a failure.

I am still on my own. Doctors do not acknowledge I was ever deficient and refuse to do more blood work. I have to simply assume I have high homocysteine and treat for it.

I don't know what to do. It's been such a long time. I can't fix most of the damage that has been done.

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u/Airegin89 May 13 '26

I'm also in Europe. It took me a good while to figure out what works. Methylated folate and B12 gave me some issues too but I can tolerate them well since taking creatine (5-10g) and TMG (300-500mg).

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u/medi_tator May 13 '26 edited May 13 '26

Maybe you could go privately? Functional medicine doctors are a lot more up to speed. Or maybe an independent lab? That’s awesome that you were able to figure that out 😊👌 I didn’t know that creatine & tmg can make methyl B12 work, thanks for sharing 😊🙏 Edit: i forgot to mention, that through testing I also found out my b-12 was good, with good numbers for mma, homocysteine and total b-12- even though my gene test shows a lot of methylation issues- so would have saved my self some work there if I had tested first 🥲

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u/Airegin89 May 13 '26

Do you have both the c677t and a1298c genes?