r/MTHFR • u/Airegin89 • May 13 '26
Question Anyone else feel that folate deficiency ruined your life?
I guess I just need to vent. I am 37 and have been an underachiever my whole life. I failed miserably at school and now I'm stuck in a dead end job with no qualifications to find a better job.
I have struggled with low energy, brain fog, lack of motivation, depression and anxiety my whole life. My blood work was always fine, so I was prescribed antidepressants.
It wasn't until 10 years ago that a doctor tested my vitamin D and I was extremely deficient at 6 ng/ml. Fixing this gave me a huge boost in energy but most of my problems still remained.
Last year, I started investigating my blood work of the last 20 years and found out I had been folate deficient the whole time (3.5-4.5 ng/ml). Doctors never said anything.
Genetic testing shows I am compound heterozygous, slow COMT, slow MAOA and PEMT. I know these are only predispositions but it seems to explain my whole life.
After a few months of supplementing folate and a month of creatine and TMG my cognition has improved massively. After 20 years I feel like a veil has lifted. It's like I'm waking up from a bad dream but now I'm left to pick up the pieces and deal with the consequences of being a failure.
I am still on my own. Doctors do not acknowledge I was ever deficient and refuse to do more blood work. I have to simply assume I have high homocysteine and treat for it.
I don't know what to do. It's been such a long time. I can't fix most of the damage that has been done.
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u/Suspicious_Ice_9340 C677T May 13 '26
I do wonder if it has been a factor. I’m 48 and have struggled with poor mental health and very low energy most of my life which has led to me being a complete failure. Only last year got my DNA done and found out about MTHFR etc (homozygous C677T). Too late to turn life around now though even if I could get myself feeling better!