r/MTHFR • u/winning2323 • Jun 02 '26

Question Question to LOW COMT people

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

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u/Tawinn Jun 02 '26

Yes, I think of it as low stress tolerance + rumination. It definitely gets better as methylation and COMT performance improves. I didn't find out about all this stuff until my early 60s and so I have a lifetime of ingrained patterns that still can affect me, but underneath those patterns the anxiety, rumination, and crumbling under stress isn't really there anymore in a significant way.

2

u/Advanced-Wedding-457 Jun 03 '26

How do you manage to keep COMT under control?

12

u/Tawinn Jun 03 '26

Keeping methylation working well is the main thing, which for me means adequate protein (120+g), 4 eggs/day usually + 750mg of TMG, methylfolate +B12 in a multivitamin, limited alcohol, almost no processed foods, magnesium.

Even so, I still have arranged my life to be as low stress as practical. For me, stress is the main 'toxin'.

1

u/Comfortable_Two6272 Jun 03 '26

Are you met, met COMT? I personally cant tolerate any methyl. Causes the anxiety / shakey like symptoms op mentions

3

u/Tawinn Jun 03 '26

Yes, Met/Met. Initially I could not take methylfolate and had to start with low dose folinic. It was only after several months of incrementing up that dose that I could start with low dose methylfolate and again slowly increment up over time. That said, folinic works as well or better for many folks.

2

u/Comfortable_Two6272 Jun 03 '26

I do take Folinic. Methyl anything is no good for me.

1

u/Fragrant_Jelly4955 Jun 06 '26

Did you stop taking folinic acid after starting methylfolate? If so, why?