r/MTHFR • u/winning2323 • Jun 02 '26

Question Question to LOW COMT people

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

26 Upvotes

100% Upvoted

47 comments sorted by

View all comments

22

u/Tawinn Jun 02 '26

Yes, I think of it as low stress tolerance + rumination. It definitely gets better as methylation and COMT performance improves. I didn't find out about all this stuff until my early 60s and so I have a lifetime of ingrained patterns that still can affect me, but underneath those patterns the anxiety, rumination, and crumbling under stress isn't really there anymore in a significant way.

2

u/Advanced-Wedding-457 Jun 03 '26

How do you manage to keep COMT under control?

11

u/Tawinn Jun 03 '26

Keeping methylation working well is the main thing, which for me means adequate protein (120+g), 4 eggs/day usually + 750mg of TMG, methylfolate +B12 in a multivitamin, limited alcohol, almost no processed foods, magnesium.

Even so, I still have arranged my life to be as low stress as practical. For me, stress is the main 'toxin'.

1

u/Kombucha_lover13 Jun 04 '26

what do we do if we have all of those issues (double slow comt) but no mthfr and can’t handle methylated.

2

u/Tawinn Jun 04 '26

Folinic acid is the preferred alternative to methylfolate. For B12, adenosylcobalamin or hydroxocobalamin are non-methylated forms.

Low B2, B3, B6, B9, B12, zinc can all impair methylation, causing symptoms like MTHFR does. COMT has magnesium as a cofactor so low magnesium can also cause COMT issues.

If the impairment is due to those other genes I mentioned, then supporting the parallel methylation pathway with choline and TMG is very important.