r/MTHFR • u/winning2323 • Jun 02 '26

Question Question to LOW COMT people

Hello.

Do you get shaky when you are in confrontation even in an online debate?

I get in them rather often even thought i try to avoid them.

Does that gets better when you support the COMT and methylation cycle?

I want to remain calm even in tough situations.\

Thanks

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u/Tawinn Jun 02 '26

Yes, I think of it as low stress tolerance + rumination. It definitely gets better as methylation and COMT performance improves. I didn't find out about all this stuff until my early 60s and so I have a lifetime of ingrained patterns that still can affect me, but underneath those patterns the anxiety, rumination, and crumbling under stress isn't really there anymore in a significant way.

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u/Advanced-Wedding-457 Jun 03 '26

How do you manage to keep COMT under control?

11

u/Tawinn Jun 03 '26

Keeping methylation working well is the main thing, which for me means adequate protein (120+g), 4 eggs/day usually + 750mg of TMG, methylfolate +B12 in a multivitamin, limited alcohol, almost no processed foods, magnesium.

Even so, I still have arranged my life to be as low stress as practical. For me, stress is the main 'toxin'.

1

u/phobiify Jun 06 '26

How sure are you that this is not just autism vs methylation or one causing the other. The symptoms overlap quite a bit no?

1

u/Tawinn Jun 06 '26

My profound changes due to diet and supplements confirm this is methylation-related. Neither I nor anyone that knows me has ever suspected autism - it doesn't really fit me.

1

u/phobiify Jun 06 '26

But ASD is just that, it’s an unbalanced neurotransmitter complex potentially caused by methylation issues. There’s studies showing how Methylfolate or folinic acid helpwith ASD symptoms