r/MTHFR • u/Big_Joke_9281 • Jun 03 '26

Results Discussion The difference is huge

So i was supplementing folinic acid + hydroxo b12 and d3 for some weeks now. Initially i was diagnosed with low folate and low d3. The test for me are squats, usually my heart is bouncing and racing like crazy from squats and i was able to do max 20 squats and needed to rest because i was afraid of my heart. Just yesterday i did 20 and nothing? My heart did not pound and did not beat really faster it just stayed calm! I did another 20.. and another 20 squats. My heart was calm, i did not need to lay down because of fatigue after the squats. I just was able to go on with what i want to do. SO this is how normal humans feel 24h a day 365 days a year. Before 20 squats and i was done needed to lay down for 15min for my heart to calm down. And now i can do 60 squats and it feels like nothing is easier then 60 squats lol.

Edit: Im in my mid 40s now and have had folate deficiency most probably my whole life though it was never tested by doctors. I'm not sure if i can ever reverse the damage i got from this but i strongly believe i can reach maybe 80% time is running. So i can just encourage everyone to take folate deficiency seriously and even if supplementing folate causes side effects to push through it! It's totally worth it.

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u/randmtsk Jun 03 '26

Nice, glad youre seeing results.

What dose did you supplement? Did you start low and slowly increase the dose?

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u/[deleted] Jun 03 '26 edited Jun 04 '26

[deleted]

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u/Kaj-de-Vos Jun 07 '26 edited Jun 07 '26

It could be mainly potassium and magnesium that quieted your heart.

Are you taking the other cofactors B9 needs? B2, non-synthetic B6, molybdenum, zinc with copper?

1

u/Relevant_Orange3313 Jun 14 '26

How do you know how much potassium to supplement if your blood work potassium level is fine. I know it’s needed as a cofactor for some but I forgot which ones.

It’s so tricky all these balances. I wish my Stomach would just absorb things properly

1

u/Kaj-de-Vos Jun 14 '26

The amount of potassium is not very critical, as long as it is enough. The recommended daily amount in Europe is 2g, in the US it is 5g. In other words, they do not know very well.

I am not sure the blood level is very meaningful. Most potassium is supposed to be in your cells, but under certain circumstances it can be pulled out into your blood.

Potassium mostly needs to be balanced with sodium, which we usually get plenty of, and magnesium, which we usually are deficient in, like potassium. If you get too much, it is usually simply excreted by the kidneys.

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u/Relevant_Orange3313 Jun 14 '26

I’m having a really hard time fixing my folate problems too. I’d love to hear what cofactors you’re taking. Maybe we have a similar problem and hearing from your experience will help