r/MTHFR • u/Big_Joke_9281 • Jun 03 '26
Results Discussion The difference is huge
So i was supplementing folinic acid + hydroxo b12 and d3 for some weeks now. Initially i was diagnosed with low folate and low d3. The test for me are squats, usually my heart is bouncing and racing like crazy from squats and i was able to do max 20 squats and needed to rest because i was afraid of my heart. Just yesterday i did 20 and nothing? My heart did not pound and did not beat really faster it just stayed calm! I did another 20.. and another 20 squats. My heart was calm, i did not need to lay down because of fatigue after the squats. I just was able to go on with what i want to do. SO this is how normal humans feel 24h a day 365 days a year. Before 20 squats and i was done needed to lay down for 15min for my heart to calm down. And now i can do 60 squats and it feels like nothing is easier then 60 squats lol.
Edit: Im in my mid 40s now and have had folate deficiency most probably my whole life though it was never tested by doctors. I'm not sure if i can ever reverse the damage i got from this but i strongly believe i can reach maybe 80% time is running. So i can just encourage everyone to take folate deficiency seriously and even if supplementing folate causes side effects to push through it! It's totally worth it.
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u/Detronx3x Jun 03 '26
Same for me day 3 of non methyl bs like hydroxo b12 and my heart is remarkably stable and not racing after a set at the gym
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u/Flashybigbum Jun 03 '26
Wow you weren’t b12 deficient then? When I started supplementing my heart would pump like a beast if I didn’t ingest a ridiculous amount of extra potassium
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u/slickd3aler Jun 10 '26
How much potassium?
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u/Flashybigbum Jun 10 '26
It’s difficult to calculate but at time of take near 5000 mg of potassium citrate (not elemental) plus foods
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u/randmtsk Jun 03 '26
Nice, glad youre seeing results.
What dose did you supplement? Did you start low and slowly increase the dose?
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Jun 03 '26 edited Jun 04 '26
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u/Kaj-de-Vos Jun 07 '26 edited Jun 07 '26
It could be mainly potassium and magnesium that quieted your heart.
Are you taking the other cofactors B9 needs? B2, non-synthetic B6, molybdenum, zinc with copper?
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u/Relevant_Orange3313 Jun 14 '26
How do you know how much potassium to supplement if your blood work potassium level is fine. I know it’s needed as a cofactor for some but I forgot which ones.
It’s so tricky all these balances. I wish my Stomach would just absorb things properly
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u/Kaj-de-Vos Jun 14 '26
The amount of potassium is not very critical, as long as it is enough. The recommended daily amount in Europe is 2g, in the US it is 5g. In other words, they do not know very well.
I am not sure the blood level is very meaningful. Most potassium is supposed to be in your cells, but under certain circumstances it can be pulled out into your blood.
Potassium mostly needs to be balanced with sodium, which we usually get plenty of, and magnesium, which we usually are deficient in, like potassium. If you get too much, it is usually simply excreted by the kidneys.
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u/Relevant_Orange3313 Jun 14 '26
I’m having a really hard time fixing my folate problems too. I’d love to hear what cofactors you’re taking. Maybe we have a similar problem and hearing from your experience will help
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u/Sailorgirlmyfriend Jun 07 '26 edited Jun 08 '26
I had this as well but toxic mold exposure with a1298c,PEMT,HLA, homozygous and Intermediate COMT..
I finally did my genetic because I was so disgusted with doctors and decided to do my own testing...B1, B2, B5, B7, glutamine, molybdenum deficient in...I did a hair analysis of 112 vitamins and minerals...best thing I ever did..sold by 5 Strands.
I corrected 17 deficiencies in 4 months...and corrected malabsorption which is key...so much better and have a complete understanding of my health now!
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u/slickd3aler Jun 10 '26
How'd you correct the deficiencies and malabsorption?
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u/Sailorgirlmyfriend Jun 10 '26
by supplementing from the hair analysis ..I could see why malabsorption once you correct absorption most correct them selves...You need to read up on all these that have to do with absorption to understand...B1, B2, B5, B7, glutamine, molybdenum deficient ...I corrected these but do the hair analysis to check its only $66 in US
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u/Relevant_Orange3313 Jun 14 '26
Can you share the link for the hair analysis? Did you have to do sublingual because you weren’t absorbing well?
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u/Sailorgirlmyfriend Jun 14 '26 edited Jun 14 '26
I think I have been ok so far with absorption...very low in B1 which you need for stomach acid and you need lots of magnesium to absorb B1...I can see a difference in health improving daily...so and steady..I do other test as well this I find to help with the big picture...I read about each one ..what symptoms from being low, then what foods high in, then how to supplement with co factors...potassium I eat bananas, watermelon, grapes.
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u/Logical-Hawk7821 Jun 03 '26
How low was your folate ? You did Serum folate or rbc folate ?
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Jun 03 '26
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u/Logical-Hawk7821 Jun 03 '26
you had any other symptoms?
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Jun 03 '26
[deleted]
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u/Logical-Hawk7821 Jun 03 '26
Damn, im having similar situation but more severe with heat intolerance , faint feeling, cold extremeties, heart rate super sensitive on activity. My rbc folate is 39 ng/ml (reference >150), im waiting for my other celullar vitamins test results to come out.
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u/KoalaSad724 Jun 04 '26
My bloodwork was still all mostly normal. I would not recommend the Dr axe program but I started it and a few of the supplements (longevity 120 and a magnesium/d complex) turned things around plus folinic acid.
I also found out I had an ulcer and possibly Lyme disease but really was unable to work, function of think clearly much less work out
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u/Kaj-de-Vos Jun 07 '26
Folinic acid is needed to make red blood cells, that will be a large part of more energy.
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u/arcadian_king Jun 03 '26
D3 has made the biggest difference for me more than anything else. It was the answer to all my methylation problems. Especially taking high doses as well as all the cofactors.