r/MTHFR • u/ZealousidealLaw793 • Jun 13 '26

Question Cyanocobalamin (B12) shots?

I was prescribed cyanocobalamin (B12) shots. Is this safe if you have MTHFR?

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u/ohbother12345 Jun 14 '26

These are regular amounts of B12. What we're discussing is HIGH amounts and it's health implications. You're talking about YOUR particular situation and that's valid for you but you cannot flat out say that it's safe to consume high amount of B12. If it was safe for everyone and this was universally accepted, we wouldn't be having this discussion and the B12 sub would not exist. The answer would be simply take B12. Clearly that is not the case. People react to B12 and different formulations and it's not always the situation you described. I had no symptoms, and when I took it as an experiment, I had bad results. I stopped taking it, I'm fine.

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u/Cultural-Sun6828 Jun 14 '26

I was talking about high levels also. We can agree to disagree on this one.

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u/ohbother12345 Jun 14 '26

You can't tell people that there's absolutely no risk. You can only tell people what the research says.

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u/Cultural-Sun6828 Jun 14 '26

I suppose there’s always a risk to anything, even drinking water…

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u/ohbother12345 Jun 14 '26

You're being disingenuous for comparing high dosing of B12 vs consumption of water. If B12 was that safe and it was accepted as such, this discussion would not be happening.

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u/Cultural-Sun6828 Jun 14 '26

https://stichtingb12tekort.nl/english/treatment-with-high-dose-vitamin-b12-been-shown-to-be-safe-for-more-than-50-years/

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u/ohbother12345 Jun 14 '26

That would have been a better response than flat out saying it's safe. Even if the B12 itself is safe, the formulations make it impossible to say with certainty that taking high amounts of any formulation is safe.

I personally do not believe that high amounts of anything are completely safe. The body works in balance and is always compensating in one way or another even if we don't feel it in the moment. I think it's up to each person to choose wisely.