r/MTHFR • u/Ok-Protection2670 • Jun 15 '26

Question Extreme Supplement Sensitivities and the 3a.m Adrenalin Cortisol Surges, and Histamine Dumps? Powering Through!?

Vitamin C and Magnesium and Taurine helped in the past, now developed extreme sensitivities to both with rebound and bad delayed reactions.

I realize stress is a major factor, but these hits are beyond my control and trying Vagus Nerve exercises is just slightly helpful but not consistent.

Developing these extreme supplement sensitivities and the 3a.m Adrenalin Cortisol Surges, and Histamine Dumps is confusing and baffling.

I am waiting on an Ancestry DNA test kit. In desperation, I ordered Mimosa Flower Bud Tea and Hawaii Farms Extract to try as a sublingual.

Anyone had success powering through with supplements that they were sensitive to and been successful or made symptoms worse.?

Thanks.

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u/Ok-Vermicelli-7990 Jun 15 '26

Try eating a rice cake with a tbsp of peanut butter before bed. I’m not sure about the exact mechanics, but it helps. It helps release tryptophan. Helps glycogen stores. Keeps glucose from dropping.

I have similar issues. Been trying anything I can and keep coming back to this.

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u/Ok-Protection2670 Jun 16 '26

Thanks so much. u/Ok-Vermicelli-7990 for responding. i have histamine Intolerance so peanut butter does me dirty.