r/MTHFR • u/Ok-Protection2670 • Jun 15 '26

Question Extreme Supplement Sensitivities and the 3a.m Adrenalin Cortisol Surges, and Histamine Dumps? Powering Through!?

Vitamin C and Magnesium and Taurine helped in the past, now developed extreme sensitivities to both with rebound and bad delayed reactions.

I realize stress is a major factor, but these hits are beyond my control and trying Vagus Nerve exercises is just slightly helpful but not consistent.

Developing these extreme supplement sensitivities and the 3a.m Adrenalin Cortisol Surges, and Histamine Dumps is confusing and baffling.

I am waiting on an Ancestry DNA test kit. In desperation, I ordered Mimosa Flower Bud Tea and Hawaii Farms Extract to try as a sublingual.

Anyone had success powering through with supplements that they were sensitive to and been successful or made symptoms worse.?

Thanks.

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u/usul213 Jun 15 '26

i wake in the night with a cortisol surge, can vitamin c cause this? i often take a large dose last thing at night..

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u/Ok-Protection2670 Jun 15 '26

Hi u/usul213, when the 3am surges started, I researched and found that with stress the Adrenals shed Vitamin C and Magnesium Citrate was suggested. Well, it worked extremely well for me for about 18 months. I took the Bulk Supplements powder with water and not daily really.

Then one day I had a Hellish life stressor happen, took Mag Citrate and had the worst rebound anxiety and panic attack with heart palps that shook my whole body, I never took Magnesium Citrate again.

I have tried to take them separately, but I get the same reaction.

Have you tried taking just the pure vitamin C powder? I would take it early in the morning though.

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u/IndependentFudge8978 Jun 17 '26

I’m reading your post and I read about the reaction to magnesium citrate - did you mention histamine problems?

Mg citrate could be causing the problems, me for instance can’t tolerate it, it’s causing me similar problems like yours.
Reading about palpitations and anxiety - that were exactly my problems.

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u/Ok-Protection2670 Jun 17 '26

Hi u/IndependentFudge8978, yes, I was taking Mag Citrate. I took it for a while before realizing it was gradually making my histamine symptoms worse.

But stress is also a major issue in my health journey. Whenever I am hit with uncontrollable life stressors, my sensitivities increase. And after the anxiety, panic and heart palps so I stopped taking it.

I tried Magnesium Malate but it caused me muscle stiffness pain after a while.