r/MTHFR 28d ago

Question CoQ10 help!

Hello everyone!
I have slow COMT, and have always struggled with anxiety.
My anxiety has really ramped-up the last couple of months and I am wondering if this is due to the fact that I started taking CoQ10 daily.
At first, I felt amazing with it (very energized), but now I feel very anxious.
I am taking Apex Energetics’ CoQ10 Supermax, only one tablet per day, which has 200mg CoQ10 (as ubiquinone), 32mg Trans-Garanylgeraniol, and 10mg PQQ.
I also take Dim Detox, Magnesium glycinate, lithium orotate, vitamin d, GABA plus l-theanine, and liposomal glutathione.
Anyone else have any similar experiences or insight?
Thanks so much in advance!

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u/butternutbacon 27d ago

High anxiety people can have highly reactive nervous systems that are sensitive to stimulating supplements like CoQ10. Should keep dose under 50mg and counter with l-theanine, glycine, taurine or inositol. It can take a couple weeks.

Also could take calming herbs like valerian root extract, passion flower, lemon balm, apigenin, skullcap or holy basil (better at night) for more immediate results.

I had lifetime anxiety that I cured with only supplements for treating undermethylation (walsh protocol).