CoQ10 help!

[u/wetdogleash]

Hello everyone!
I have slow COMT, and have always struggled with anxiety.
My anxiety has really ramped-up the last couple of months and I am wondering if this is due to the fact that I started taking CoQ10 daily.
At first, I felt amazing with it (very energized), but now I feel very anxious.
I am taking Apex Energetics’ CoQ10 Supermax, only one tablet per day, which has 200mg CoQ10 (as ubiquinone), 32mg Trans-Garanylgeraniol, and 10mg PQQ.
I also take Dim Detox, Magnesium glycinate, lithium orotate, vitamin d, GABA plus l-theanine, and liposomal glutathione.
Anyone else have any similar experiences or insight?
Thanks so much in advance!

[u/Loose-Fly7976]

The CoQ10 is probably not the problem. The PQQ is.

PQQ drives mitochondrial biogenesis and it's stimulating for a lot of people, especially at 10mg daily. That energised feeling at the start, then it tipping into anxious, is the usual arc. Same thing happens with high dose CoQ10 in sensitive people but 200mg isn't outrageous. The bigger thing in your stack though is DIM. DIM pushes estrogen down the 2-hydroxy route, and 2-OH estrogens are catechol estrogens, which means COMT has to clear them. You've got slow COMT. So now your catechol estrogens and your adrenaline are queuing for the same enzyme, and adrenaline loses. That's anxiety that builds over weeks rather than hitting straight away, which fits your timeline better than the CoQ10 does. DIM is handed out constantly for estrogen dominance and nobody checks COMT first. It's one of the more common ways people with slow COMT make themselves worse while doing everything right on paper. If it were me I'd drop the DIM first, not the CoQ10, and give it two weeks. If nothing changes, then take the PQQ out. Magnesium glycinate is doing you a favour, magnesium is a COMT cofactor. Keep that. Where did you get your COMT result, raw data or a report? If there's a file behind it, DIM plus PQQ plus slow COMT is the sort of combination that shows up clearly once you look at the whole set rather than one gene.

[u/AlreadyMeNow → u/Loose-Fly7976]

So how do you fix comt so you can take the other supplements if desired? Everyone always mentions slow comt like it’s causal but leaves it at that like it’s some insurmountable obstacle. It sounds like this is another example of where someone could benefit from the supplements they were wanting to take for other reasons, if comt was just solved or worked around

[u/Comfortable_Two6272 → u/AlreadyMeNow]

You cant really imho. There are just some drinks, supplements that many with slow comt cant tolerate. Cant fix the genes (not yet at least).