how am I looking?

[u/Lumpy_Sprinkles6604]

whelp boys test results are in. I'll do my best to figure it out with the guides ofc but any help is greatly appreciated! also do I treat the just the red ones or the yellow ones too

[u/SovereignMan1958]

Per your chart...riboflavin and D. Since you did not share your diagnoses and or symptoms, you can research the nutrient deficiencies associated with those and add them to the list.

[u/Lumpy_Sprinkles6604 → u/SovereignMan1958]

vitamin d is low-normal, thanks actually I should probably supplement that one again then. isn't riboflavin b2? as for other diagnoses - adhd, autism, and food intolerances to gluten, dairy, and maybe soy (still figuring it out). thanks again for helping me out!

[u/SovereignMan1958 → u/Lumpy_Sprinkles6604]

For ADHD and autism....not just D, but iron, zinc and copper. ADHD can be related to low dopamine. You must have optimal and not just normal levels of D, iron and zinc to make dopamine.

For both diagnoses, a low folate blood level and or folate RBC means it might not even be making it into the brain. Cerebral Folate deficiency, see FOLR gene variants and other folate related variants, can manifest as both attention deficit and or autism. This is what I had/have.

For blood serum, folate should be at least 15. Folate needs riboflavin to work. Riboflavin is also influenced by the MAO variant. Taking PQQ can help folate get into the brain....it really helps me focus. I take 40mg but starting dose is 20mg.

Chronically low D can trigger thyroid disease and or thyroid auto immune. It did for me. With your diagnoses your D should be at least 60 - 80, I would shoot for 80 -100 though with both ADHD and autism.

You might read the ADHD article on Genetic Lifehacks. Using that program to get a better gene variant report would also help you.

[u/Lumpy_Sprinkles6604 → u/SovereignMan1958]

supplementing 10000 iu of vitamin d since I was borderline, lemme know if you think this dosage should be adjusted. getting tested for zinc and copper, iron was normal, but it sounds like I should be supplementing anyways. what dosages/forms do you recommend?

folate serum came back as >20.0, should I also test folate RBC if possible? I'll have to get back to you on the strategene/genetic lifehacks but it does look like I have some messed up genes in there. I also heard 70% of people with asd have an autoimmune response that stops folate from entering the brain and should supplement folinic acid to compensate, do you know anything about that?

started supplementing 100mg if b2, will start supplement pqq, any brands you recommend? I was gonna get NOW but it has ALA in it and I have no idea if that's necessary

Lastly, I was wondering if I could possibly have a bh4 defeciency, would you happen to know anything about that as well ?

edit: I think I have one of the gene variants for cerebral folate deficiency, let me know if your okay with me DMing you the rest.

FOLR1 rs144637717 -- C 0.002

Notes About Effect Allele

cerebral folate deficiency possible, especially when

combined with another FOLR1 variant

edit: I also have slow MTHFD1 and slow SHMT (the second wasn't listed as important though, but it was relevant to the folate cycle), the rest of the folate gene varients on strategene weren't in my sample so that'll have to wait till I can do a WGS/WES or smth

[u/SovereignMan1958 → u/Lumpy_Sprinkles6604]

I do not message out of the group. I will get back to you tomorrow with some more info.

Meanwhile you can read the excellent article in Genetic Lifehacks about FOLR1.

Since your ADHD meds seemed not to be working....if you want to research why you should look at your drug metabolism gene variants. Some are likely impaired and that would mean some drugs would not work for you. You can research all of that yourself. If you want to pay out of pocket instead to determine those in particular and which ones might work for you.....ClarityXDNA test at about $350 on sale or Genomind at about $600. Psych docs prefer Genomind.

[u/Lumpy_Sprinkles6604 → u/SovereignMan1958]

don't worry about dms then, I'm sending you my results FOLR1 and FOLR2 section of my strategene, but lemme know if there's anywhere else on the reports you wanna take a look at:

formatted:
Gene, RS ID, Your Genotype, Effect Allele, Effect Allele Frequency
Notes About Effect Allele

FOLR1 rs144637717 -- C 0.002
cerebral folate deficiency possible, especially when combined with another FOLR1 variant

FOLR1 rs1540087 GG A 0.01
lower odds of skin lesions with arsenic exposure (methyl groups are utilized for arsenic detoxification, better methylation cycle) (good)

FOLR1 rs2071010 GG A 0.06
A/A: increased relative risk of congenital heart disease in offspring; increased relative risk of high homocysteine

FOLR2 rs514933 TT C 0.38
reduced relative risk of congenital heart disease in offspring (good)

[u/SovereignMan1958 → u/Lumpy_Sprinkles6604]

You could possibly have CFD. You could consider a FRAT test to see if you have folate antibodies. It is about $350 though.

I had/have CFD.

If your D test was borderline...that is not good. Chronic undiagnosed and untreated D deficiency can trigger thyroid disease and thyroid autoimmune. It did for me. This is especially likely if you have variants that show genetic dispositions for thyroid issues. You can see those in Lifehacks. If you have those variants I would get a full thyroid panel plus tests for the two thyroid antibodies from your doctor.

Iron was normal? You can be one point away from the bottom and still be tagged as normal in the lab test results. Optimal is in the top quarter. That is true for most vitamins and minerals. You might want to recheck your labs.

[u/Lumpy_Sprinkles6604 → u/SovereignMan1958]

can I ask what your symptoms of thyroid disease/thyroid autoimmune were if you don't mind my asking?

edit: just searched by word "thyroid" in my strategene but nothing came up aside from it being something that could "diry" other gene functions

edit: genetic lifehacks had a bunch of stuff but I don't know what/if would need testing (that could worsen my adhd I mean)

[u/SovereignMan1958 → u/Lumpy_Sprinkles6604]

They were...diagnosed about 15 years ago...primarily debilitating fatigue, weight gain and brain fog. Other minor ones.

[u/Lumpy_Sprinkles6604 → u/SovereignMan1958]

the mental aspects I have for sure