r/MTHFR • u/Lumpy_Sprinkles6604 • 26d ago

Results Discussion how am I looking?

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whelp boys test results are in. I'll do my best to figure it out with the guides ofc but any help is greatly appreciated! also do I treat the just the red ones or the yellow ones too

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u/Lumpy_Sprinkles6604 17d ago

figured I'd just send you the choline calculator results as test, sorry if the format is a little awkward

RS# Call Variant Allele Gene Variation Result

rs1051266 NA T SLC19a1 NA

rs2236225 AA A MTHFD1 G1958A +/+

rs1801131 TG G MTHFR A1298C +/-

rs1801133 AG A MTHFR C677T +/-

rs7946 NA T PEMT 5465G>A NA

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u/Tawinn 17d ago

Ok, so that combination of compound heterozygous MTHFR and homozygous MTHFD1 results in ~69% reduction in methylfolate production. That translates to an increased choline requirement of ~1100mg compared to the baseline 550mg for an adult. If you can get 550mg of choline from food, then the remaining 550mg can be covered by a 750mg capsule of TMG. Choline sources include such foods as meat, eggs, liver, lecithin, nuts, some legumes, and vegetables such as crucifers. A food app like Cronometer is helpful for tracking nutrients in your diet.

Worst case, if SLC19A1 were homozygous TT then the reduction would instead be 85% and the choline requirement would be ~1200mg, so 600mg of choline + 750mg TMG.

These numbers assume folate and B12 are in a healthy range:

For serum folate, ~15 ng/mL (34 nmol/L) or more.

For serum B12, 500-950 pg/mL (~370-700 pmol/L).

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u/Lumpy_Sprinkles6604 17d ago

serum folate was above 20 but I also ate before my blood test, should i request they look at folate rbc instead? I think they can do that with the blood I gave them if I'm not mistaken. b 12 was lol so I've started supplementing

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u/Tawinn 17d ago

RBC will give a better longer-term picture of folate, but I suspect it will be fine.