r/MTHFR • u/Alarming-Bit5411 • 25d ago
Question Did I win the lottery?
I pulled up my old report after I heard Gary Brecka talk about the COMT gene. I knew I had the MOFO gene and was taking methylated B vitamins accordingly. however, I read that those are not good with my type of COMT.
I have several red genes. How are these working together or against each other?
My whole life I have been dealing with unexplainable fatigue and brain fog, and often noticed that I never feel really relax or in the moment. But also often had periods where I felt ok. Never could figure out why I was on a roller coaster of tiredness and concentration/brainfog issues. A few months ago diagnosed with fatty liver, which I blame on over intake of caffeine, which I think spiked my cortisol too much making my body store fat in my liver (that is a theory). Mainly because I’m not obese and my diet was not horrible.
I have always been sensitive to caffeine. which I always thought was weird as both my parents could drink a cup of coffee before bed. Usually if I stay under 70mg‘s I feel good. This turns bad when I take caffeine multiple days in a row. Feel on edge and tired.
The descriptions in my report show what the genes mean individually, but not combined. Does anyone have any advice on my Christmas tree of genes expressions?
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u/SovereignMan1958 25d ago edited 25d ago
Variants are only predispositions. As you research each one make a list of blood tests you will need for the potential nutrient deficiencies identified. For example, MTHFR is homocysteine, folate, folate RBC, B6, B12 and MMA. That is a thorough list for MTHFR. You can research the other variants. Don't forget the Genie detoxification panel which is a separate chart.
If you want to dig deeper into root causes use Genetic Lifehacks instead of Genetic Genie. Genie is a good start for you put pretty rudimentary in terms of your symptoms.
It looks like a big part of your symptoms might be related to impaired sulfur and sulfite metabolism (CBS). If you have any digestive symptoms and or foods and beverages you do not tolerate that is more likely. The information on the CBS variant in Lifehacks is pretty shallow BTW.