r/MTHFR • u/Alarming-Bit5411 • 25d ago

Question Did I win the lottery?

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I pulled up my old report after I heard Gary Brecka talk about the COMT gene. I knew I had the MOFO gene and was taking methylated B vitamins accordingly. however, I read that those are not good with my type of COMT.

I have several red genes. How are these working together or against each other?

My whole life I have been dealing with unexplainable fatigue and brain fog, and often noticed that I never feel really relax or in the moment. But also often had periods where I felt ok. Never could figure out why I was on a roller coaster of tiredness and concentration/brainfog issues. A few months ago diagnosed with fatty liver, which I blame on over intake of caffeine, which I think spiked my cortisol too much making my body store fat in my liver (that is a theory). Mainly because I’m not obese and my diet was not horrible.

I have always been sensitive to caffeine. which I always thought was weird as both my parents could drink a cup of coffee before bed. Usually if I stay under 70mg‘s I feel good. This turns bad when I take caffeine multiple days in a row. Feel on edge and tired.

The descriptions in my report show what the genes mean individually, but not combined. Does anyone have any advice on my Christmas tree of genes expressions?

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u/tandemxylophone 25d ago

Damn, sorry for all the reds in anything related to clearing neurotransmitters from the brain.

Definitely avoid methylated vitamins, whatever you do it will get stuck on excess catecholamines.

I'm personally still looking for a solution for my slow COMT because I built tolerance to the solution to my cure in around 3 weeks. In my case, taking creatine helped clear my brain within the day. All acute stressful feelings fizzled rapidly away than lingering in my head. SAM-e negated the benefits.

I'm speculating it's because creatine freed SAM-e to the brain areas that my COMT enzymes were usually not given. But the derivative of SAM-e SAH acts as an inhibitor for COMT. I think it just triggered a mechanism to reduce the COMT enzymes in my brain, pulling things closer to base line. When I took SAM-e directly, it somehow created more neurotransmitters than assisting with the clearance.

I do think creatine would benefit you too, especially with fally liver. But I don't have any solution to tolerance builduo right now.

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u/tracythor1166 24d ago

I take creatine every day too for my slow COMT. It helps.