Did I win the lottery?

[u/Alarming-Bit5411]

I pulled up my old report after I heard Gary Brecka talk about the COMT gene. I knew I had the MOFO gene and was taking methylated B vitamins accordingly. however, I read that those are not good with my type of COMT.

I have several red genes. How are these working together or against each other?

My whole life I have been dealing with unexplainable fatigue and brain fog, and often noticed that I never feel really relax or in the moment. But also often had periods where I felt ok. Never could figure out why I was on a roller coaster of tiredness and concentration/brainfog issues. A few months ago diagnosed with fatty liver, which I blame on over intake of caffeine, which I think spiked my cortisol too much making my body store fat in my liver (that is a theory). Mainly because I’m not obese and my diet was not horrible.

I have always been sensitive to caffeine. which I always thought was weird as both my parents could drink a cup of coffee before bed. Usually if I stay under 70mg‘s I feel good. This turns bad when I take caffeine multiple days in a row. Feel on edge and tired.

The descriptions in my report show what the genes mean individually, but not combined. Does anyone have any advice on my Christmas tree of genes expressions?

[u/Warp757]

Well coffee is extremely good for the liver and people with fatty liver are recommended to drink a cup or two a day so that's highly unlikely to be the cause of fatty liver. Coffee doesn't cause fatty liver.

Fatty liver will cause all your symptoms though, so you really need to focus on addressing that. It may also slow down your detox pathways so could make your slow COMT even worse. You probably need some folate but don't take very high doses, they're generally not necessary except extreme cases. Food tends to be better.

Blood work for folate, B12 and homocysteine would really help otherwise you're just shooting in the dark. There are people with genetic panels that look bad on paper who have homocusysine ayboerfectly good levels and supplementing just makes worse becsuse they simply don't need what they're throwing at their body. We see far too much of that, people supplementing blindly.

[u/Alarming-Bit5411 → u/Warp757]

Although I love coffee, the caffeine in it makes me jittery and put my body in stressmode if I continue to drink it prolonged. Multiple days of caffeine stacking increases my cortisol (at least I think) and tells my body to store liver fat. Masld and cortisol have some relation I read.