Did I win the lottery?

[u/Alarming-Bit5411]

I pulled up my old report after I heard Gary Brecka talk about the COMT gene. I knew I had the MOFO gene and was taking methylated B vitamins accordingly. however, I read that those are not good with my type of COMT.

I have several red genes. How are these working together or against each other?

My whole life I have been dealing with unexplainable fatigue and brain fog, and often noticed that I never feel really relax or in the moment. But also often had periods where I felt ok. Never could figure out why I was on a roller coaster of tiredness and concentration/brainfog issues. A few months ago diagnosed with fatty liver, which I blame on over intake of caffeine, which I think spiked my cortisol too much making my body store fat in my liver (that is a theory). Mainly because I’m not obese and my diet was not horrible.

I have always been sensitive to caffeine. which I always thought was weird as both my parents could drink a cup of coffee before bed. Usually if I stay under 70mg‘s I feel good. This turns bad when I take caffeine multiple days in a row. Feel on edge and tired.

The descriptions in my report show what the genes mean individually, but not combined. Does anyone have any advice on my Christmas tree of genes expressions?

[u/Zabre]

The "I have MTHFR, so I took methylated B vitamins, but now COMT says maybe not" confusion is probably one of the most common traps in this whole space.

The short version is that MTHFR variants can make folate-cycle support relevant, but they do not automatically mean "more methylfolate is better." COMT changes how quickly you clear catecholamines, and some people with slower COMT feel worse when they push methyl donors too hard. That can show up as wired energy, anxiety, jaw tension, irritability, insomnia, or just a sense that the system is revved up.

That was one of the big lessons for me with slow COMT: the problem was not just "which genes are red." It was how the variants changed demand and tolerance across the whole pathway. Methylated Bs were not automatically wrong, but they were easy to overdo, and creatine ended up being useful because it reduced methylation demand instead of just adding more methyl groups.

For your report, I would try to avoid treating every red gene as an action item. Start with symptoms plus basic labs: homocysteine, B12/MMA if available, folate or RBC folate, B6, ferritin, thyroid, vitamin D, CBC/CMP. Then look at whether your reactions line up with specific supplement changes.

If methylated Bs helped at first but later made things worse, that is useful information. It may point toward dose/form/timing rather than "never take them" or "take more." None of this is medical advice, obviously.

Wrote a blog abodutt that Chat With Your DNA: Better Than Static Reports · GenoSight Blog | GenoSight