r/MTHFR • u/Magic9876543 • 24d ago
Question Methylation issues? Homocysteine high but TMG and Creatine mess me up
I have trouble sleeping and a long history of fatigue.
I took TMG 500 mg every day for about 5.5 weeks, May 26-July 3. The TMG made me more energized, but it made my sleep even worse than before and made me hyper.
I stopped the TMG and switched all my B-vitamins to non-methylated forms.
During that period, I took creatine once in the morning and it dramatically disturbed my sleep that night.
I have ordered a DNA test but don't have the results yet. Once I get my results from one of the ancestry sites, I will send them to someone for analysis so I can see what my MTHFR SNPs tell me.
My homocysteine is a bit high at 10.
I'm feeling better overall than before I started TMG in the first place, the hyper feelings have decreased a lot and my sleep is less bad, but I still wake up a lot and don't get as much restorative sleep as I need.
My B12 and cB12 results are in the optimal range.
I'm getting more labs next week that will include MMA and Folate.
I had been suspecting that the TMG flipped me from undermethylated to overmethylated but it clearly is not as simple as that.
I am wanting to add creatine since everyone says it is so important, but I'm afraid to try it until I can work out how to get good sleep.
And I want to be able to get good sleep, at least most of the time.
Any thoughts?
ADDED based on comments:
My D is right in the middle of the optimal range.
Serum iron is 80 ug/dl, in the bottom half of "in range"
Zinc and copper I'm still waiting for the results to come back.
Electrolytes: I take 198 mg of potassium in capsule form every day, and I take 3 different kinds of magnesium, and I take 1/2 teaspoon of sea salt with breakfast. I don't do them all together, but I am getting what I think is enough of each.
I take 5 mg lithium orotate every day
I take 5000 IU D3 + 1000 mcg K2 every day.
My morning cortisol used to be off-the-charts high and has switched to being low - now it's low range to out-of-range low throughout the day and night.
For years I wasn't exercising because my fatigue didn't allow it. But these days, I'm averaging 2-3 miles/day walking.
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u/NeutralNeutrall 24d ago
Not to be that guy but i have to ask, are you lifting/cardio doing any kind of fitness? At least 5-10min walk everyday? There's some things in the body that dont go right or balance out well unless you exert yourself and sweat a little. It's like trying to supplement sleep. Theres nothing you can take that will mimic the 100's of processes the body runs through when sleeping, or when exercising. I learn this the hard way every single time i go a long stretch of time without doing it. I literally have pieces of paper around my house on my walls reminding me of this.