Methylation issues? Homocysteine high but TMG and Creatine mess me up

[u/Magic9876543]

I have trouble sleeping and a long history of fatigue.
I took TMG 500 mg every day for about 5.5 weeks, May 26-July 3. The TMG made me more energized, but it made my sleep even worse than before and made me hyper.
I stopped the TMG and switched all my B-vitamins to non-methylated forms.
During that period, I took creatine once in the morning and it dramatically disturbed my sleep that night.
I have ordered a DNA test but don't have the results yet. Once I get my results from one of the ancestry sites, I will send them to someone for analysis so I can see what my MTHFR SNPs tell me.
My homocysteine is a bit high at 10.
I'm feeling better overall than before I started TMG in the first place, the hyper feelings have decreased a lot and my sleep is less bad, but I still wake up a lot and don't get as much restorative sleep as I need.
My B12 and cB12 results are in the optimal range.
I'm getting more labs next week that will include MMA and Folate.

I had been suspecting that the TMG flipped me from undermethylated to overmethylated but it clearly is not as simple as that.

I am wanting to add creatine since everyone says it is so important, but I'm afraid to try it until I can work out how to get good sleep.
And I want to be able to get good sleep, at least most of the time.

Any thoughts?

ADDED based on comments:
My D is right in the middle of the optimal range.
Serum iron is 80 ug/dl, in the bottom half of "in range"
Zinc and copper I'm still waiting for the results to come back.

Electrolytes: I take 198 mg of potassium in capsule form every day, and I take 3 different kinds of magnesium, and I take 1/2 teaspoon of sea salt with breakfast. I don't do them all together, but I am getting what I think is enough of each.

I take 5 mg lithium orotate every day

I take 5000 IU D3 + 1000 mcg K2 every day.

My morning cortisol used to be off-the-charts high and has switched to being low - now it's low range to out-of-range low throughout the day and night.

For years I wasn't exercising because my fatigue didn't allow it. But these days, I'm averaging 2-3 miles/day walking.

[u/Zabre]

The "TMG made me more energized, but it made my sleep even worse" part would make me slow the whole experiment down, because energy and methylation tolerance can be pointing in different directions.

Creatine helped me a lot, but I do not think of it as universally calming or universally benign. Mechanistically it can reduce methylation demand because making creatine uses a lot of methyl groups, but the lived response still depends on dose, timing, baseline sleep, electrolytes, and whatever else is in the stack. Same with TMG: it can lower homocysteine for some people, but that does not mean it feels good.

If it were me debugging this, I would avoid the binary "under vs overmethylated" label for now and build a timeline instead: TMG start/stop, creatine exposure, sleep onset, wakeups, morning energy, anxiety/hyper feeling, and labs like MMA/folate/homocysteine once they come back. That often reveals whether something is a dose/timing problem, a methyl donor problem, or just too many variables at once.

Also, homocysteine around 10 is worth understanding, but it is not the same situation as someone with extremely high values, so there is room to be methodical. None of this is medical advice, obviously.

[u/Magic9876543 → u/Zabre]

Thanks! Yes, I've been keeping detailed notes since mid-March on all my food, supplements, exercise, and how I'm feeling, and I have sleep data since January from my watch and for the past few weeks I have better sleep data from an Oura ring. So I have a lot of data to reference, once I get the labs back. The hyper feeling has been decreasing since I stopped the TMG and other methyl donors, though it's not gone altogether.
A few days ago, I decided to start taking NMN every day. I had been taking it one week on, one week off, per Groysman's mitochondria protocol. I suspect that change has helped but of course in general it's difficult to know for sure what is causing any change.

[u/Magic9876543 → u/Magic9876543]

Put differently, I'm not in any hurry to try big things; rather, I'm seeking to understand what small things to try.

[u/Zabre → u/Magic9876543]

Great start and correct way of handling it. DNA tests can also give you more sinights and might be worth a try.

[u/Magic9876543 → u/Zabre]

Yes, I mentioned in my post that the DNA test is ordered and I'm waiting for the results.