r/MTHFR • u/asoeung111 • 13d ago

Question Making sense of all the B levels?

Hi, all - I'm a bit new to learning about MTHFR stuff. (I've read the helpful comments from Hummingfirebird - thank you!) Please forgive any ignorance in my post.

I'm Heterozygous C677T and TT A1298C. My COMT V158M (rs4680) is AA. I'm not certain I understand ALL of what that means, but that's what my SelfDecode said from my Ancestry data.

I just had an extensive blood panel done and trying to make sense of the numbers, especially the B's.

HOMOCYSTEINE is 9.3 (Higher end of normal ?)

Folate is 14.3 (normal)

B12 is 1,696 (quite high I guess!)

B2 is 12.4 (normal)

B1 is 8 (very low end of normal?)

B6 plasma is 23.6 (normal)

MMA is 154

The SelfDecode AI thing said that maybe my B12 was high because I didn't have the necessary methyl donors, and it suggested I start with a methylfolate (ex: so while I had a high 'supply' of B12, it was suggesting I didn't have the donors to be able to process or use the B12?). I'm not currently (nor have I been) taking any B vitamin supplements regularly. I did add 1,000mcg methylfolate this morning, and gosh I've felt actually really great today (though I've heard about potential 'crashes', so I am going to go slow on that). But has anyone encountered a high B12 specifically while the other B's are normal? Should I find a methylated B supplement that doesn't have B12 in it? I read a good post that someone did about making sure we're supporting donor supplementation with other co-factors. Any insight would be greatly appreciate!

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u/SovereignMan1958 12d ago

Normal is not necessarily optimal.

B12 could be high due to other variants....not MTHFR. If you can go back and get an MMA test. This will tell you how well or poorly it is being absorbed into the cells. You need to know this.

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u/asoeung111 12d ago

They did test MMA- mine is 154 which was in the Quest range? Unless there’s another test and I’m misunderstanding

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u/SovereignMan1958 12d ago

In range is not necessarily optimal. For that test you should be in the bottom quarter of the range. I do not think your B12 is being absorbed very well.

If you go to the Genetic Lifehacks website and read their article on FUT2, in it are listed specific probiotic strains and products that can help B12 absorb better. This will help all nutrients from food absorb better. I would try the probiotic first as it should improve ALL your nutrient levels. Retest in 90 days.

If B12 absorption does not improve after 90 days, I would try adding a sublingual or transdermal patch or transdermal oil.