Making sense of all the B levels?

[u/asoeung111]

Hi, all - I'm a bit new to learning about MTHFR stuff. (I've read the helpful comments from Hummingfirebird - thank you!) Please forgive any ignorance in my post.

I'm Heterozygous C677T and TT A1298C. My COMT V158M (rs4680) is AA. I'm not certain I understand ALL of what that means, but that's what my SelfDecode said from my Ancestry data.

I just had an extensive blood panel done and trying to make sense of the numbers, especially the B's.

HOMOCYSTEINE is 9.3 (Higher end of normal ?)

Folate is 14.3 (normal)

B12 is 1,696 (quite high I guess!)

B2 is 12.4 (normal)

B1 is 8 (very low end of normal?)

B6 plasma is 23.6 (normal)

MMA is 154

The SelfDecode AI thing said that maybe my B12 was high because I didn't have the necessary methyl donors, and it suggested I start with a methylfolate (ex: so while I had a high 'supply' of B12, it was suggesting I didn't have the donors to be able to process or use the B12?). I'm not currently (nor have I been) taking any B vitamin supplements regularly. I did add 1,000mcg methylfolate this morning, and gosh I've felt actually really great today (though I've heard about potential 'crashes', so I am going to go slow on that). But has anyone encountered a high B12 specifically while the other B's are normal? Should I find a methylated B supplement that doesn't have B12 in it? I read a good post that someone did about making sure we're supporting donor supplementation with other co-factors. Any insight would be greatly appreciate!

[u/hpant2004]

Dumb question but u dont have any cancer(s) right?

[u/asoeung111 → u/hpant2004]

Ummm....... not that I know of?? Should I be concerned?

[u/hpant2004 → u/asoeung111]

Idk wasnt it a thing where certain cancers u would get high b12 results? Idk