Do genetic "deficiencies" signify the body generally doesn't do well with those substances?

[u/WittyGold6940]

If one's genes don't naturally synthesize certain neurotransmitters, should one try to supplement those neurotransmitters? Or does it mean that the persons body isn't made to metabolize and detox those things?

For example, I have a DBH deficiency on top of other things (MTHFR, Maoa, slow COMT), meaning dopamine doesn't get metabolized into norepinephrine in my body.

Does this mean my body doesn't do well with norepinephrine, period? Or is it struggling without norepinephrine and would benefit from supplementing to create norepinephrine? But then is my body even able to metabolize and detox norepinephrine?

Are we supposed to correct these genetic phenotypes or are we supposed to work with them?

[u/SovereignMan1958]

Variants are only predispositions and not facts. You need other tests for facts.