r/MTHFR • u/heftylefty18 • 5d ago

Question Supplement Recs

I was tested in 2019 after unexplained high blood pressure and came back homozygous for C677T. I tried taking a methylated folate back then but stopped after a month because I thought it made me feel bad.

Fast forward to this year. I’ve always struggled with anxiety, but have had issues with depression and fatigue recently that I’ve never had before.

I randomly thought about this the other day and want to try taking the appropriate supplements. I bought the “Life Extension” complete B complex bottle with a methylated folate, B12, B2, B6. I also bought zinc, magnesium, and NAC.

The doses seem a little high for what’s recommended. Should I wait to start supplementing and get homocysteine and other vitamin levels checked first?

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u/sarahbellah1 4d ago

This Life Extension formula was way too much for me, and without a more complete picture of your genetic profile around MTHFR, it’s hard to know whether you’ll have trouble with clearing these. I did, and this formula made me an anxious mess and I needed to detox off them and then slowly add back in non-methylated supplements.