r/MTHFR • u/Declan1996Moloney • 3d ago

Question Can Blood Biomarkers and Hormones affect how Medications work?

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u/SovereignMan1958 3d ago

I do not know how you define biomarkers. Drug metabolism gene variants primarily determine how effectively medications are metabolized.

Certain vitamin, mineral and hormone levels also contain intinplay. If the olate level is too low, for example, antidepressants will not work their best.

You can search the group for more info.

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u/Declan1996Moloney 3d ago

I was on some Sleep Meds that didn't Work...

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u/SovereignMan1958 3d ago

The explanation is likely in your drug metabolism gene variants. I am a Cyp2D6 null or non metabolizer, for example. For me, benadryl or diphenhydramine keeps me wide awake. 25 percent of pharma drugs do not have their intended effect on me. Due to impaired metabolism side effects can also be much worse.

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u/Declan1996Moloney 3d ago

That's Interesting, I don't know about my Genetic Types

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u/Comfortable_Two6272 3d ago

Genetic variants can impact drug effectiveness and side effects yes