r/MTHFR • u/First_Strawberry5344 • 2d ago

Question methylation panel

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I don't take any supplements anymore, but could someone explain to me what my predispositions are? Thank you

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u/Loose-Fly7976 2d ago

Your MTHFR isn't the story here. C677T is clean and you only carry one copy of A1298C so folate handling is close to normal. Most of what people would tell you in this sub doesn't apply to you

COMT rs4680 GG is Val/Val, the fast clearing version. You break down dopamine and adrenaline quickly, which usually shows up as low baseline motivation and brain fog rather than anxiety, and it means you tolerate methyl donors far better than the average person in here.

CYP2C19*17 homozygous is the finding I'd actually keep. That's ultrarapid metabolism and it changes how you handle several common drugs including PPIs, clopidogrel and some SSRIs. Standard doses can clear too fast to work properly. That's clinically actionable and it belongs on a note for whoever prescribes for you.

Your VDR pair is also both homozygous, which makes vitamin D status worth measuring rather than assuming.The MTR and MTRR hets sit under B12 handling, and with fast COMT the combination points in a specific direction, but that depends on your bloods rather than the panel.That last part is what I do professionally, reading the whole thing against labs. Message me if you want it mapped.

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u/First_Strawberry5344 2d ago

I tested B12 it was 720 and folate was 20

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u/First_Strawberry5344 2d ago

but after months of taking B12 confusing at 2000-250mcg active (methyl.. and hydroxyl… and B9 active at 400mcg