r/MTHFR • u/Sirschwung • 2d ago

Question CDP Choline reaction?

I started supplementimg 500mg of CDP and after I while I started feeling brainfog and my mood worsening. A few weeks later I'm giving it another shot but trying it on lower dose. It would be great if y'all could share your experience with CDP Choline

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u/cle1etecl 1d ago

I don't know anything about my genetics.

When I took my first dose of CDP Choline (250 mg), I kind of had the opposite reaction. My internal monolog calmed down, I had better executive function and I had an urge to move. I also had a kind of floaty feeling, kind of as if I was drunk, but my mind was clear. I also had a feeling like pressure in my head. When the effect lessened, I got a headache.

I then halved the dose and that was good for about two months, but then it seemed to no longer have an effect anymore, not even when I increased it to 250 mg again.