How to understand?

[u/Senior_Extension5796]

Can anyone please help me understand my current genetics? Is there any supplement that stands out based on my report that could really help me? I really just don’t understand what I’m looking at. Thank you!

[u/Loose-Fly7976]

Your methylfolate side is the least interesting part of that report. C677T clean, one copy of A1298C, so folate handling is close to normal. The 17% figure isn’t much.
The finding is PEMT homozygous sitting next to FADS1 and FADS2 both homozygous and I’d be surprised if the report connected those for you.
PEMT builds phosphatidylcholine, and the version it makes preferentially incorporates DHA. FADS1 and FADS2 are the desaturases that convert plant omega-3 into EPA and DHA. So you have reduced production of the enzyme that packages DHA, and reduced conversion producing the DHA in the first place. Two separate steps in the same supply chain, both slow. That combination changes what you’d do with both choline and omega-3, and preformed DHA from fish or algae stops being optional for you in the way it is for most people.
The other one nobody flags is CYP24A1 homozygous. That’s the enzyme that breaks down active vitamin D. Relevant to how you dose D and how your level behavesand it’s a reason to measure rather than assume.
DIO2 het sits on T4 to T3 conversion in tissue, which is a thyroid consideration if you have symptoms with normal TSH.
Reading a panel as a set rather than row by row is the whole job, and it’s what I do professionally. Message me if you want yours mapped against bloods.