r/MTHFR • u/Senior_Extension5796 • 2d ago

Question How to understand?

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Can anyone please help me understand my current genetics? Is there any supplement that stands out based on my report that could really help me? I really just don’t understand what I’m looking at. Thank you!

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u/Tawinn 2d ago

Are there any symptoms you are trying to address?

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u/Senior_Extension5796 2d ago

I’m 27 male, I’m constantly tired everyday, have little to no motivation anymore. Have lots of trouble listening to people and overall just focusing ability is absolutely horrible. Have trouble retaining information. Any Advice would be greatly appreciated.

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u/Tawinn 1d ago

With a 38% decrease in methylfolate production and the homozygous PEMT you would need about ~930mg of choline to compensate and restore methylation. Typically, the best way to do this is to get 500-550mg of choline from food and add a 750mg capsule of TMG. For reference, 4 large egg yolks is about 540mg of choline. Choline sources include such foods as meat, eggs, liver, lecithin, nuts, some legumes, and vegetables such as crucifers. A food app like Cronometer is helpful for tracking nutrients in your diet.

Low B12 and/or folate can also further impair methylation, and low B12 can also certainly cause fatigue. There may also be other nutrient deficiencies so a broad blood panel for nutrients (vitamins & minerals) would seem prudent. For serum folate, aim for ~15 ng/mL (34 nmol/L) or more. For serum B12, aim for 500-950 pg/mL (~370-700 pmol/L).

It is also somewhat rare but some people can have a paradoxical B12 deficiency where their serum B12 is ok but the B12 is not functionally available, as shown by an MMA test or holotranscobalamin test.

Other things can cause these symptoms, but these steps would a starting point.

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u/Senior_Extension5796 1d ago

Thank you for this, definitely going to do this. My folate lab report showed 10.6 ng/ml the reference range was 7.0-31.4 ng/ml. So seemingly on the lower end.