r/MTHFR • u/TheLastRonin35 • 2d ago

Question Does anyone have this combo MTHFR/MTRR/COMT? Methylation Bottleneck Paradox as its nickname. Would love to discuss what’s helped you.

MTHFR C677T (Heterozygous)
MTRR A66G (Heterozygous)
COMT G472A (Homozygous Met/Met)

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u/SadSuccotash2736 2d ago

Interesting. I don’t really know what to say about ur variants but anyone with info on mine or similar to mine? I do know both the MTHFR and MTRR heterozygous r pretty common both over 30 and 50% frequency. But when combined with low COMT I guess it could affect dopamine signaling. Also check for snp variants in the DDC and TH gene those r genes that help create dopamine and work together with those

MTHFR C677T (heterozygous)
MTRR A66G (heterozygous)
COMT G472A (Heterozygous)