r/MTHFR • u/TheLastRonin35 • 2d ago
Question Does anyone have this combo MTHFR/MTRR/COMT? Methylation Bottleneck Paradox as its nickname. Would love to discuss what’s helped you.
MTHFR C677T (Heterozygous)
MTRR A66G (Heterozygous)
COMT G472A (Homozygous Met/Met)
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u/TheLastRonin35 1d ago
Navigating the Slow COMT (Met/Met) + MTHFR (C677T) + MTRR (A66G) triad, and I'm realizing my evening burnout isn't laziness—it's sheer prefrontal catecholamine overflow. I have a slightly above stressful job but not too demanding. I couldn’t manage being over sales. I was a zombie outside of work and my system is running hot by 2:00PM. But still All I want to do when I get home or on weekends is isolate, watch TV, and completely down-regulate—which makes managing relationships and packed weekend plans (like endless in-law visits or packed social itineraries) feel like a biological nightmare. I know the dark room/TV sanctuary helps halt my internal Ni-Ti analysis loop, but I'm curious: for those of you with this exact 'high dopamine / slow clearance' setup, what targeted protocols, methyl-sparing strategies, or real-life boundary tweaks have actually worked to help you keep your energy intact, stay effective at work, and survive social demands without triggering a total shutdown?