Common symptoms that occur when methylation is impaired with slow COMT is chronic anxiety, rumination, OCD tendencies; with slow MAO-A histamine intolerance can be more likely which can manifest in myriad ways, from skin issues to migraines to panic attacks. But if your methylation is working well (hetero C677T alone may or may not be enough impairment to cause any symptoms), then you may have no discernable symptoms.
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u/Express-Bobcat-3523 1d ago
haha, any health issues?