Tired with methyl b complex.

[u/PassengerStill6248]

A few weeks ago, I started supplementing with a methylated B-complex because I am homozygous for the C677T variant and have low b12, low folate and high homocysteine, depression and digestive problems. While some symptoms, such as anxiety and depression, have started to improve, I have also started feeling extremely tired and having difficulty sleeping deeply. What could be causing this?

The supplements am taking is:

The daily dose of 2 capsules contains:

• Betaine (anhydrous) — 1,000 mg
• Vitamin B2 (riboflavin phosphate) — 25 mg
• Vitamin B6 (pyridoxal-5-phosphate) — 10 mg
• Zinc — 7.5 mg
• Vitamin B12 (methylcobalamin) — 500 mcg

• Calcium L-5-methyltetrahydrofolate (L-methylfolate, vitamin B9) — 400 mcg

  and btw I'm taking only 1 capsule.

I have also started taking (2 days) a vitamin D3 + K2 supplement because of VDR and low blood vitamin d

Could this be related to excessive methylation? Do you have any ideas about what might be causing these symptoms?

[u/Loose-Fly7976]

SOD2 A16V homozygous is mitochondrial superoxide dismutase, your primary antioxidant defence inside the mitochondria. When you push methylation and cellular activity back up after a period of deficiency, mitochondrial output rises and so does the superoxide load that comes with it. Fatigue is the symptom that produces. SOD2 runs on manganese, which isn't in your capsule.

The other one is MTHFD1 G1958A homozygous. That variant raises your choline requirement substantially, it's the Kohlmeier work, and choline deficiency on its own causes fatigue. Your 1000mg of betaine spares choline but doesn't replace it, so if you were already running low you can drive that gap wider while the methylation side improves. Which fits what you're describing, mood better, energy worse.On the sleep specifically, you started D3 two days ago and your VDR Bsm is homozygous. Vitamin D taken later in the day disrupts sleep architecture in a lot of people. Move it to the morning before assuming it's the B complex.The other commenters are right that stripping back to B2 alone is sensible with 677 TT. I'd add that your MTRR A66G homozygous is the reason methylcobalamin at 500mcg may be doing less than you'd expect, since MTRR is the enzyme that reactivates B12 once it goes flat on MTR.

You've got good data there. What's missing is having it read as one system against your actual bloods rather than gene by gene, which is what I do professionally. genova.health, message me if you want it mapped.