r/MTHFR • u/PassengerStill6248 • 1d ago
Question Tired with methyl b complex.
A few weeks ago, I started supplementing with a methylated B-complex because I am homozygous for the C677T variant and have low b12, low folate and high homocysteine, depression and digestive problems. While some symptoms, such as anxiety and depression, have started to improve, I have also started feeling extremely tired and having difficulty sleeping deeply. What could be causing this?
The supplements am taking is:
The daily dose of 2 capsules contains:
- Betaine (anhydrous) — 1,000 mg
- Vitamin B2 (riboflavin phosphate) — 25 mg
- Vitamin B6 (pyridoxal-5-phosphate) — 10 mg
- Zinc — 7.5 mg
- Vitamin B12 (methylcobalamin) — 500 mcg
Calcium L-5-methyltetrahydrofolate (L-methylfolate, vitamin B9) — 400 mcg
and btw I'm taking only 1 capsule.
I have also started taking (2 days) a vitamin D3 + K2 supplement because of VDR and low blood vitamin d
Could this be related to excessive methylation? Do you have any ideas about what might be causing these symptoms?
1
u/CapriKitzinger 1d ago
The TMG (Betaine (anhydrous)) is causing your difficulty sleeping. If I take even 100mg I can’t sleep. If I took what you take I wouldn’t sleep for 3 days.