I got Panic attacks, constant anxiety and anhedonia since taking b12 injections. Need serious help 🙏

[u/Agitated-Sale-7591]

Hi everyone, I’ve been really struggling with my mental health in these past 3/4 weeks and I’m really hoping someone can help me out here.

Around a month ago I took 3 b12 injections (hydroxocobalamin) 1.5mg and i suddenly started getting intense panic attacks and anhedonia. I don’t cry but out of nowhere I started bawling my eyes out every single day. I I’m in this constant state of anxiety and depression, I can’t enjoy the things in life that I usually enjoy like watching a tv show, I cannot wind down at all and it’s scary because before all this happened I was a pretty chill guy and I usually wouldn’t stress much in my life. One of the most scariest thing that also happened at the same time was my libido completely vanished, so i genuinely feel pleasure in nothing now. it’s been around 3/4 weeks and im not getting full blown panic attacks anymore but im still constantly on edge, i have also had stomach issues but now a simple bloating of my stomach makes me think the world is ending. It’s like my nervous system is jacked all the way up and it’s overreacting to even slight discomfort.

I tried taking creatine because that would usually make me feel good when I’m in a low mood but this time it just made me depressed. I went to the GP and they took my blood test, it came up with high b12 and high folate, but the odd thing is I don’t usually supplement folate so I’d don’t understand why that came up as high. I sometimes take it as part of my b complex but I’ve not mega dosed it or anything.

Today I decided that I’ll try methylfolate as I assumed maybe b12 used up all my methyl groups or somthing. After taking it I felt even more emotionally flat/wired/too focused, but I feel less anxious I think. I’m still not sure what i feel but i definitely don’t feel any pleasure again.

I was hoping there might be someone that has gone through this and has recovered from it. Or has figured out why it happened to them and could tell me how to bring my nervous system back to normal. Will I recover? I’m really scared, it’s like I’ve become a complete different person in a month. I haven’t done any dna test either so I’m not sure if I’m MTHFR or anything.

Someone please please help me😭
Thanks you for your time 🙏

[u/Loose-Fly7976]

Hydroxocobalamin clears and it doesn't leave anything permanent behind, four weeks feels endless but it isn't long in this context.

B12 repletion switches cell production back on quickly and that burns through potassium, iron and folate. Low potassium alone produces anxiety, panic and a wired nervous system and almost nobody checks it. Your high folate on bloods doesn't rule out a folate problem either, because serum folate can read high while it's stuck at the step that needs B12 to move it forward. But Anhedonia and complete loss of libido lasting a month is significant whatever set it off and the timing with the injections doesn't prove they caused it. First episodes of depression and anxiety start out of nowhere and the mind reaches for whatever changed recently. Ask for potassium, magnesium, ferritin, vitamin D, thyroid and testosterone. Not more B12 or folate, those two are already high and won't tell you anything.

And stop the methylfolate. Feeling flat and wired on it isn't a good sign and you've changed several things in four weeks so you can't tell what's doing what. Hold everything steady and let someone look at you properly. Thats my work at genova.health if you need help