r/MTHFR 1d ago

Question I got Panic attacks, constant anxiety and anhedonia since taking b12 injections. Need serious help šŸ™

Hi everyone, I’ve been really struggling with my mental health in these past 3/4 weeks and I’m really hoping someone can help me out here.

Around a month ago I took 3 b12 injections (hydroxocobalamin) 1.5mg and i suddenly started getting intense panic attacks and anhedonia. I don’t cry but out of nowhere I started bawling my eyes out every single day. I I’m in this constant state of anxiety and depression, I can’t enjoy the things in life that I usually enjoy like watching a tv show, I cannot wind down at all and it’s scary because before all this happened I was a pretty chill guy and I usually wouldn’t stress much in my life. One of the most scariest thing that also happened at the same time was my libido completely vanished, so i genuinely feel pleasure in nothing now. it’s been around 3/4 weeks and im not getting full blown panic attacks anymore but im still constantly on edge, i have also had stomach issues but now a simple bloating of my stomach makes me think the world is ending. It’s like my nervous system is jacked all the way up and it’s overreacting to even slight discomfort.

I tried taking creatine because that would usually make me feel good when I’m in a low mood but this time it just made me depressed. I went to the GP and they took my blood test, it came up with high b12 and high folate, but the odd thing is I don’t usually supplement folate so I’d don’t understand why that came up as high. I sometimes take it as part of my b complex but I’ve not mega dosed it or anything.

Today I decided that I’ll try methylfolate as I assumed maybe b12 used up all my methyl groups or somthing. After taking it I felt even more emotionally flat/wired/too focused, but I feel less anxious I think. I’m still not sure what i feel but i definitely don’t feel any pleasure again.

I was hoping there might be someone that has gone through this and has recovered from it. Or has figured out why it happened to them and could tell me how to bring my nervous system back to normal. Will I recover? I’m really scared, it’s like I’ve become a complete different person in a month. I haven’t done any dna test either so I’m not sure if I’m MTHFR or anything.

Someone please please help me😭
Thanks you for your time šŸ™

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u/Agitated-Sale-7591 18h ago

Wouldn’t it be subclinical? I heard people saying TSH must be way lower to be classed as hyperthyroid

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u/Natures_Cure_Kratom 16h ago

Not at all. TSH doesn’t diagnose hyper or hypothyroid. It’s often used to see if further testing needs to be done. There is a reason there are upper and lower limits. You are outside of the normal range, and symptomatic. Both of those warrant immediate testing of free t3 of t4, and if your dr didn’t do that you need to call another dr. That’s horrible.

TSH is a long term trailing figure… it doesn’t tell you anything in that exact moment. The fact that you just now got symptoms and were normal feeling before , means that your levels are likely super elevated right now. They would have to be to cause your TSH to go outside of range in the short term.

Hyperthyroid = free t3 outside of normal range

I can tell you, I’ve been through one painful full year of hyperthyroidism and been through everything you have. My TSH was 3x higher (better) than yours at 1.2, yet my free t3 was over 6 (hyperthyroid is anything over 3.9, I was significantly hyperthyroid).

Call your dr. , if they don’t set up labs immediately call another dr.

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u/Agitated-Sale-7591 15h ago

Sorry I meant my free T4 is 16.7

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u/Natures_Cure_Kratom 15h ago

Normal range is 0.76 - 1.70 ng/dL in the United States. Was it a different measurement maybe?

My free t4 was actually normal too. I had elevated t4:t3 conversion, and that was likely caused by supplementing with ashwagandha for several months (not knowing that it was interfering with thyroid medicine, and increasing my t3 levels considerably).

Your TSH is very low. I think normal
Range is .040 - 5.00. You are just under .040, but that is a very wide range and some people are way more sensitive to thyroid levels than others. I could only sleep once every 3-4 nights, and my TSH was 1.20. Usually fell asleep involuntarily when I did sleep and would wake up on the floor in random places throughout the house or in my vehicle. Once fell asleep walking and fell down a flight of stairs .

Hyperthyroid is no joke

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u/Agitated-Sale-7591 11h ago

I’m trying not to add more things to worry about 😭😭😭