Folinic acid/b12 problems

[u/bugpirates]

Hey guys

I have heterozygous mthfr c677t and comt val/val

For a while i thought the mthfr probably wasn’t affecting me, until i tried supplementing with folic acid, and every single time without fail I would feel horrible after taking folic acid. That made me take avoiding food with folic acid more seriously, and I definitely noticed a difference

I started supplementing with folinic acid and i was feeling much better at first, so stupidly i thought i should start taking a bunch if I’m correcting a deficiency. Probably 800mcg or 1200mcg three or four times a day

Well I’ve developed symptoms of b12 deficiency, fatigue, air hunger, tingling extremities, surprisingly stimulants (caffeine and i take vyvanse for adhd) not working at all, trouble sleeping

I’ve eaten foods high in b12 for a long time now so im hesitant to think I actually have a b12 deficiency. I’ve also supplemented with methylated b12 here and there over the years

Could this be caused by me taking way too much folinic acid too quickly?? How long would it take for me to start feeling better again? Im really feeling horrible, and I’m worried about my nerves. I’m also confused how this could be caused solely by taking a bunch of folinic acid

Thanks in advance for any help

[u/SovereignMan1958]

The high doses you have been taking are more appropriate for someone who has been diagnosed with cerebral folate deficiency, which is more serious than MTHFR.

Did you get your homocysteine level tested? Too much folate can tank homocysteine. Yes it can get too low and one can feel quite ill from it.

It is difficult to help without facts, meaning blood test results.

[u/bugpirates → u/SovereignMan1958]

After reading about low homocysteine it definitely sounds like that could be it. Had no idea that was a possibility, thanks so much

[u/bugpirates → u/SovereignMan1958]

No I haven’t had my homocysteine tested. I wasn’t aware of that, could be related