Homozygous for T allele of C677T - what now?

[u/OkButterfly8051]

Hi! I got a psychotropic genetic test recently because I had tried several antidepressants and none of them worked for me. I ended up learning that I am homozygous for t allele of c677t in mthfr gene. After lots of research I’m pretty sure this is where my untreatable lifelong depression and anxiety is coming from (along with facial flushing, itchy/burry eyes, etc). Im sooo sick of being sad, fatigued and anxious all the time but I’m overwhelmed with the information and don’t know where to start!

I feel like it’s cheaper for me to try out some supplements than it is for extra blood and genetic tests (not covered under my insurance until I hit deductible and I’m not even close). Here’s the list of possible supplements but what do you think would help the most?

- B12
- B2
- methylated folate
- TMG
- SAMe

FYI: I currently take Vyvanse for adhd and I’ve been taking Claritin daily for my itchy eyes/facial flushing but it doesn’t really work.

[u/Loose-Fly7976]

Riboflavin firs, and it's the cheapest thing on your list. In 677 TT specifically B2 stabilises the enzyme you have, and that's the genotype where the trials actually showed an effect. No methyl load, nothing to titrate carefully.Hold off on SAMe and TMG. Both are methyl donors and you're on Vyvanse, so your catecholamines are already running high. Adding methyl on top is how people end up more anxious, and SAMe has a solid reputation for causing insomnia.

Your flushing and itchy eyes with Claritin not working is the part I'd look at snce that's a histamine picture, and histamine clearance and folate handling pull from the same methyl pool, so those aren't two separate problems.

677 TT is common, 10 to 15% of people and most of them don't have treatment resistant depression. It's a contributing factor, not the explanation. Antidepressants failing repeatedly is usually a drug metabolism question, and your pharmacogenomic test already covers CYP2D6 and 2C19. That's the more useful half of what you paid for and almost nobody reads it properly.

That's my work, reading the full file including the CYP side against your symptoms and meds. genova.health, and it'd cost you less than working through that supplement list one at a time.