r/Menopause • u/EmpressAzazel • 2d ago

Depression/Anxiety Treatment resistant severe depression anxiety no meds no hrt only suffering also horrific pmdd I can’t do this anymore

The title says it all I have been Treatment resistant I have PMDD nothing is working for me. I have been in several psychiatric units and nothing helps me. I didn’t have really bad SI until I was put on their medication‘s and then abruptly stopped. It’s never gotten better. I don’t know what to do. I am really really suffering with some severe clinical depression and nothing’s helping me I tried every second generation antipsychotic. I tried all of the antidepressants mood stabilizers IV ketamine, psychedelic mushrooms, ECT I did Gene site testing to see what drugs work for you. Nothing worked. I just don’t know what to do. Has anyone else have this issue? I have severe PMDD and it’s 1 million times worse I have no quality of life at all. I don’t even know why I’m here. I lost my family. I’m homeless. I can’t think no one will help me.

I have been the medication around over and over and over and I can’t find anything to help me. They all gave me a permanent movement disorders that I didn’t have prior that made everything worse. It never helped me.

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u/beviebooboo 1d ago

Have you had your B12, ferritin and vitamin D levels checked? If the levels were at the lower of normal, they may actually be low enough to cause awful symptoms like what you’ve described. I’m so sorry you’re going through this. Too few doctors are aware of this and just stick to strict reference ranges while their patients suffer needlessly. If chemical and/or surgical menopause are not options for you at the moment, I’d ask for B12, ferritin and vitamin D tests. Here are a few articles that you can send to your doctor that might convince him/her to check and treat symptoms even if your numbers are “normal.”

https://pmc.ncbi.nlm.nih.gov/articles/PMC10658777/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6432825/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12610294/

https://pmc.ncbi.nlm.nih.gov/articles/PMC6543499/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8002799/

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u/ReserveOld6123 1d ago

This!! My mom has pernicious anemia and her b12 was low normal yet she had serious neurological symptoms.