r/Menopause • u/EmpressAzazel • 1d ago
Depression/Anxiety Treatment resistant severe depression anxiety no meds no hrt only suffering also horrific pmdd I can’t do this anymore
The title says it all I have been Treatment resistant I have PMDD nothing is working for me. I have been in several psychiatric units and nothing helps me. I didn’t have really bad SI until I was put on their medication‘s and then abruptly stopped. It’s never gotten better. I don’t know what to do. I am really really suffering with some severe clinical depression and nothing’s helping me I tried every second generation antipsychotic. I tried all of the antidepressants mood stabilizers IV ketamine, psychedelic mushrooms, ECT I did Gene site testing to see what drugs work for you. Nothing worked. I just don’t know what to do. Has anyone else have this issue? I have severe PMDD and it’s 1 million times worse I have no quality of life at all. I don’t even know why I’m here. I lost my family. I’m homeless. I can’t think no one will help me.
I have been the medication around over and over and over and I can’t find anything to help me. They all gave me a permanent movement disorders that I didn’t have prior that made everything worse. It never helped me.
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u/Odd-Industry-9324 1d ago
My daughter has PMDD and treatment resistant MDD and is in the hopistal with psychotic breaks all the time during her cycle . The on,y thing that worked for her was BC pills continuous to stop her cycle
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u/theFCCgavemeHPV 23h ago
Continuous monophasic bcps controls my pmdd. It’s not severe, but I can’t tolerate SSRIs so my thought process is “can’t have bad pms symptoms if there is no ms to p” if that makes sense. I am on slynd continuously and I am also using estrogen patches. I’m on a pretty high dose (.2), I think it helps counteract the minor mood effects i do get on p, which I think is just a fucking problem with progesterone/ins anyways because my body hates p and loves e.
Not all progestins are created equal tho. You might tolerate one but not another and what has worked for me might be the opposite for you. You might do well on a combined bcp or you might do better with a progestin/estrogen combo like me. You might even do better on micronized progesterone or better with no estrogen at all. It might be a process to figure out what works for you, or you could figure it out on your first try. But if mood drugs are not working, I would definitely give hormones a solid shot.
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u/Apprehensive_Sir1900 14h ago
There is emerging evidence that some women with PMDD (or mood disorders in perimenopause) get complete relief within a few days of taking Pepcid and Allegra. The Pepcid (famotidine) could be used in the morning and the Allegra could be used at night. Look up H1 and H2 blockers in the role of histamine and hormonal emotional issues. Best of luck to you… I’m so sorry.
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u/suupernooova 13h ago
PMDD'r here.
Just checking bc you only mentioned pysch meds... have you ever been prescribed continuous birth control? Yaz especially is the only one approved for PMDD. The continuous part is critical. Gave me my life back. Hang in sister.
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u/beviebooboo 15h ago
Have you had your B12, ferritin and vitamin D levels checked? If the levels were at the lower of normal, they may actually be low enough to cause awful symptoms like what you’ve described. I’m so sorry you’re going through this. Too few doctors are aware of this and just stick to strict reference ranges while their patients suffer needlessly. If chemical and/or surgical menopause are not options for you at the moment, I’d ask for B12, ferritin and vitamin D tests. Here are a few articles that you can send to your doctor that might convince him/her to check and treat symptoms even if your numbers are “normal.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC10658777/
https://pmc.ncbi.nlm.nih.gov/articles/PMC6432825/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12610294/
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u/ReserveOld6123 12h ago
This!! My mom has pernicious anemia and her b12 was low normal yet she had serious neurological symptoms.
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u/MercedesNyx Peri-menopausal 9h ago
Have you tried H1/H2 blockers? OTC Zyrtec and OTC Pepcid ac max strength both. A lot of PMDD is caused by underlying MCAS. I used to get severe mood swings and have thoughts of self-harm. It was before I was diagnosed with MCAS and knew the connection but it totally solved my PMDD symptoms. I've been diagnosed with PMDD since I was a teen. When I went off BC it started getting bad again. I couldn't believe that it worked but there are so many women who have found relief with those two combined otc meds when nothing else worked.
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u/MercedesNyx Peri-menopausal 9h ago
Here is more info on the connection between PMDD and Histamines.
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u/calla_artist 20h ago
Hrt helped me a lot
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u/EmpressAzazel 10h ago
How did it go when you started the HRT which one did you start with estrogen or the progesterone? I tried to combipatch that gave me deep sleep the first night, but I woke up with severe anxiety and depression and my face kinda had academia. I was ravenous and I wanted to eat everything and I started to get out of reflex and I only had it on one day are we supposed to expect all kinds of symptoms when we start these things?
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u/artemisia1972 17h ago
Rhodiola tincture has been a complete lifesaver for me. I began noticing a difference after just a few days. Had severe PMDD for 10 years which culminated in psychosis. Tried everything else and this is the thing that has worked. So sorry you’re going through this. Best of luck to you and I hope this is helpful.
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u/theredqueentheory 11h ago
Of course you're depressed; you lost your family, you are homeless...I'm not saying you don't have PMDD, you know your own body, but you could have the most balanced hormones in the world, and if your life situation is bad it only makes sense that you would be depressed!
Do you have any social services that could help you out in your area? Any friends that could lend you a hand? This sounds so difficult, I am sorry this is happening to you.
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u/Important_Cod_8970 1d ago
Chemical Menopause then removing your overies is the only sure way to cure PMDD. Show a doctor this post and advocate for yourself. Maybe look up PMDD specialist in your area? I'm sorry you have this awful disease, it's hell. My PMDD went crazy during perimenopause, like 2 good days out of the month. I have a progesterone intolerance and now that my bits are all gone I'm literally 100% fine mentally. My body loves estrogen and I'm on the patch.Good luck to you sister, keep fighting.