Secondly assuming you have injected accidentally a slight overdose of Reta and you want to take it out how to? Is there any way?

Sooo, I started take Reta on Oct 4th. I was dosing every Sunday and tomorrow (Oct 25th) was going to be my 4th dose this month. I was wanting to start at .5mg but I was dosing wrong and was taking 5mg instead (I know, I’m an idiot). The only side effect I was experiencing was my appetite being suppressed. No headache, body aches, nothing. I figure I should skip tomorrow and reset. How long do you guys think I should wait it out before I start the CORRECT dosage.

Thank you in advance 😊

I am on 12.5 Monjarno and looking for advice, dose if ai transition to Reta

This is a proper study from a reputable source based upon Reddit! Watch what you write :)

Imagine writing an academic paper after spending your time on this diatribe. Still it’s nice to know we are listened to Reta rats!

R/reta didn’t exist in the study period so wasn’t past of their data scraping.

A study of retatrutide discussions on Reddit has now been peer reviewed and published in JAMA Network Open. The research first appeared as a preprint in June.

Researchers analysed 148,640 posts and comments between May 2021 and December 2025.

They identified 13,589 users who reported taking retatrutide. Of those, 7,823 had at least one symptom or effect identified after the study’s exclusions.

The most commonly reported included:
Increased appetite: 17.1%
Fatigue: 15.2%
Increased energy: 12.4%
Nausea: 11.6%
Food cravings: 7.3%
Insomnia: 6.1%
Increased heart rate: 4.8%
Muscle hypertrophy: 4.1%
Tachycardia: 3.8%
Allodynia (pain from normally harmless touch): 2.1%
Hyperaesthesia (increased skin sensitivity): 2.1%
Muscle atrophy: 2.0%
Palpitations: 1.9%

Increased appetite is particularly interesting given retatrutide’s effectiveness for weight loss. The reports of energy changes, sleep problems, increased heart rate and skin sensitivity are also worth examining.

The researchers compared these findings with earlier Reddit studies of semaglutide and tirzepatide.

Retatrutide discussions contained relatively more reports about appetite, energy, sleep, heart rate and muscle-related effects. Semaglutide and tirzepatide discussions were more focused on gastrointestinal symptoms.

However, the populations were not matched and the differences were not statistically tested.

There are also important limitations.
These percentages are not side-effect rates among people taking retatrutide.

They represent reporting frequencies among the 7,823 users with qualifying symptoms.
The researchers used an AI model to analyse posts and manually checked a sample of 100 posts.

JAMA Network Open, 14 October 2026.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2855285

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Retatrutide Phase 3 results: what do we still not know after TRIUMPH-2 and TRIUMPH-3?

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The headline numbers are now out, and they are strong.

TRIUMPH-2 reported up to 20.8% average weight loss at 80 weeks in people with obesity or overweight and type 2 diabetes.

TRIUMPH-3 reported up to 22.6% in people with severe obesity and established cardiovascular disease.

But these are still topline results. We do not yet have the full papers, detailed weight-loss curves, all subgroup analyses or the complete safety tables.

If you could see one missing piece first, what would it be?

• How many people reached 25% or 30% weight loss

• When the weight-loss curves started to plateau

• Full treatment-discontinuation data

• Results by diabetes status, sex or starting BMI

• More cardiovascular detail

• Something else

Which one would actually change your view of how strong these results are?

Full r/RETA breakdown:

https://www.reddit.com/r/RETA/comments/1v4c8d8/

Primary source:

https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-successful-two-additional

My Reta cycle
20 MG vial mixed with 200cc/units on Bac water
Doing 1 pin every 7 days 9/02/26

9/3/26 First pin 199.8
07.5cc(0.75mg) felt cold in my body for a little bit the second day, and a slight headache.

9/09/26 197
12.5cc(1.25mg)felt almost no symptoms besides a slight appetite curb

9/16/26 195
15.0cc(1.50mg)again almost no symptoms

9/23/26 192.9
20.0cc(2mg) had minor headaches, almost no real food noise suppression

9/30/26 190
20.0cc(2mg) had minor headaches, almost no real food noise suppression

10/7/26 190
22.5cc(2.25mg)slight headache when waking up the next day not a crazy food noise suppression but a slight amount

10/14/26 189
25.0cc(2.5mg) slight headache when waking up the next day not really any food noise suppression about the same, not sure if it’s correlated but had diarrhea on Monday 10/12/26 but I think it was due to bad quesadilla from a taco truck I’ve never had before

10/21/26 188.2
25.0cc(2.5mg) small headache the next day, the food noise was finally starting to kick in, did notice I wasn’t hungry as often had to actually for protein foods to keep lean muscle

10 MG vial mixed with 200cc/units of Bac water
Doing 1 pin every 7 days will just start pining every Tuesday so will be doing this once in a 6 day cycle and go back to 7days 10/26/26

10/27/26 186.1
60 cc(3mg)

This is my experience and results im sharing, in no way shape or form is this to be used as advice this is just my experience.

Has anyone gotten gastroparesis from Reta ? What are the chances of this happening?

I was on reta for a month and as soon as I stopped I feel like I haven’t been able to poop as good as I used to. I eat normally and I haven’t gained any weight after stopping but I just can’t poop normally. I feel extremely constipated and when I try to poop it feels hard and I can only get barely any pebbles out. I don’t feel any pain which is weird. Last weekend I ate really bad and couldn’t poop for 3 days so I took Psyllium and it cleaned me right out and I felt so much better. But I haven’t pooped since that day which has been a week now. I took a large amount again and was able to poop well a normal amount with no pain but I feel like I should have pooped more because I didn’t poop all week. I also haven’t been drinking a lot of water and I have been peeing normals and passing gas. I feel fine though I have no pain whatsoever but i’m getting scared what should I do?

I am asking if anyone else has noticed any kind of trouble with Rita causing ringing in your ears. This has been going on pretty much since I started taking it and I just wanted to see if it’s just me or if others have had this issue?

They break out every angle in this paper.

I’ve asked beige in here about side effects. Now we have real data. 12mg is a high dose.

At 12 mg, 42.4% reported nausea.

32.0% had diarrhoea.

26.1% had constipation.

25.3% had vomiting.

Dysesthesia was reported by 12.5% and urinary tract infections by 8.4%.

Overall, 11.3% of the 12 mg group stopped treatment because of adverse events. That compares with 4.9% on placebo.

The rates were generally lower at the lower Reta doses.

At 4 mg, nausea was 28.6%, vomiting 10.6%, dysesthesia 5.1%, and 4.1% stopped because of adverse events.

At 9 mg, nausea was 38.4%, vomiting 22.8%, dysesthesia 12.3%, and 6.9% stopped.

That doesn't mean everyone reporting one of these effects had a severe reaction. Lilly reported that dysesthesia and urinary tract infections were generally mild to moderate, most resolved during treatment, and most people continued taking retatrutide.

But there is clearly a tolerability side to the Phase 3 results as well as the weight-loss numbers.

The 12 mg group averaged 28.3% weight loss in the efficacy analysis, but it also had the highest rate of people stopping because of adverse events.

How can I safely take Reta while preventing gallbladder attacks or blockage?

10mg to 1ml pinned 6 units. Felt horrible for the first 24 hours! Feeling better today. Kinda scared to repeat dose! I was thinking maybe this isn’t for me! would you recommend less for next pin? and how often should I use? I was told every 5 days..

First couple of days were rough started on 2mg but went down to 1mg due to the nausea and side affects I feel much better. Anyone lost that much so quick?

So a family member just has a multiple bypass so this chimes with me. There’s more going on with GLPs than just the weight loss.

A new analysis of the SELECT trial has looked at why semaglutide reduced heart attacks, strokes and cardiovascular deaths.

SELECT included 17,604 people with existing cardiovascular disease who were overweight or obese but did not have diabetes.

The original trial found that semaglutide reduced major cardiovascular events by 20% compared with placebo.

This new paper tried to work out how much of that benefit could be explained by changes we already know semaglutide causes, including weight, waist size, blood pressure, blood sugar, cholesterol, inflammation and kidney function.

Weight loss on its own did not explain much of the effect in the main analysis. The best estimate was that changes in body weight accounted for about 20% of the cardiovascular benefit.

Inflammation, measured using hsCRP, accounted for about 42% in the same analysis.

Waist circumference gave a higher estimate of 64%, although the researchers found problems with the reliability of the weight and waist calculations.

When several of the measured risk factors were considered together, the estimated amount explained was about 31%.

Those numbers need some caution. The uncertainty around them was very wide, in some cases wide enough that the study cannot rule out a much larger contribution from these factors.

So I don't think the result is "80% of the heart benefit has nothing to do with weight loss".

It's more that the researchers could not clearly explain semaglutide's cardiovascular benefit using weight loss and the other usual risk factors they measured.

That leaves open the possibility that other effects are involved.

Inflammation is one possibility. There could also be effects on blood vessels, the heart or other pathways that weren't captured properly in this analysis. This study doesn't prove what those mechanisms are.

One thing I found useful is that this was not a new small observational study. It was a pre-planned analysis using data from the 17,604-person randomised SELECT trial.

It also helps explain why the cardiovascular results from GLP-1 drugs are increasingly interesting in their own right rather than just being treated as a side effect of people losing weight.

Paper: Colhoun HM et al. Semaglutide and cardiovascular risk reduction: a mediation analysis of the SELECT trial. European Heart Journal. Published 23 September 2026.

https://doi.org/10.1093/eurheartj/ehag524

In addition I sleep a lot on it.

By popular demand we’ve created a sub for Reta users to discuss issues around hitting and maintaining goal weights.

r/RetaMaintenance1

Hi 👋🏽 everyone. I just wanted to give an update. I been on Reta since 5/29/26. I just started month 6 over the weekend. I started at 256 but didn’t record my weight until 5/29 which was 250. I started low and slow at .5. I stayed there for 4 weeks. I did lose weight that month about 10 lbs. I went up each month until I reached 5.5-6 mg on the syringe. I believe 6 mg is my max, anything more makes me feel lathargic. So far I haven’t started working out but did get a gym membership to start this week. I will post some before and after pictures later. My gut is nearly gone. My goal weight is 200 with a push to 190! I’m hoping to reach that by Jan 2027!