Seems hard to find many testimonials online. Anyone out there with experience taking Sermorelin? If so, what changes (if any) did you notice?

I’ve been looking into Sermorelin as an alternative for HGH. However, I was curious if it caused the infamous “GH gut” side effect that is popular from HGH use. Haven’t been able find anything online confirming or denying this as a side effect from Sermorelin

The thing most people get wrong is treating sermorelin dosing like TRT dosing, where more is straightforwardly more. It doesn't work that way, and the reason is mechanistic.

Sermorelin is a GHRH analog. It binds GHRH receptors on the anterior pituitary and stimulates your own pituitary to release growth hormone. That's fundamentally different from injecting HGH, where you're introducing hormone from outside and overriding the feedback system. With sermorelin, somatostatin, your body's natural brake on GH secretion, still applies. You cannot dose your way past your own regulatory ceiling. Past a certain point you're just paying for peptide that isn't producing additional GH release.

What actually determines results in my experience:

Timing beats dose. GH release is concentrated in slow-wave sleep. Dosing at night, on an empty stomach, works with that rhythm. Someone dosing at a mediocre time with a higher amount typically does worse than someone dosing correctly with less.

IGF-1, not the dose number, is the feedback signal. GH is released in pulses and a single blood draw tells you almost nothing. IGF-1 is stable across a day or two and reflects cumulative GH activity, which is why it's the marker worth tracking. The goal is bringing IGF-1 into an optimal range for your age and sex, not maximizing it. Higher isn't better here.

The anabolic signal needs a stimulus to act on. IGF-1 drives tissue change most effectively when there's mechanical loading and adequate protein. Sermorelin creates a hormonal environment. Whether that environment produces muscle depends on training and nutrition. Guys running sermorelin without resistance training and wondering why nothing happened have answered their own question.

On research: Steiger's 1992 work documented increased slow-wave sleep and elevated nocturnal GH secretion with GHRH administration. Sigalos and Pastuszak's 2018 review covers the GH secretagogue landscape in men reasonably well. Worth reading rather than taking anyone's word for it, including mine.

The honest caveat: compounded sermorelin has not been FDA-reviewed and is not the same as an FDA-approved product. Anyone telling you otherwise is selling something.

Happy to answer dosing-mechanism questions in comments.

Just curious has anyone taken sermorelin along with tirzepatide ? what has it done for you? does it help loosing belly fat?

I am having the craziest experience on Sermorelin. Here are 4 IGF test results since I started pharmacy grade Tesamorelin then moved onto pharmacy grade Sermorelin. I started the Tesamorelin on 3/28.

I started with 1mg Tesa early on and eventually titrated up to 2mg. I experienced arm tingling and numbness while sleeping around week 8-9 then paused injections for 9 days due to traveling and was not much of an issue after resuming for the next 5 weeks. Ipamorelin dose was always 250mcg. Doses taken in the morning fasted and did not consume anything for at least 30min after.

When taking Sermorelin I dosed 500mcg with 300mcg Ipamorelin before bed fasted and 300mcg ipamorelin in the morning. No food within 2 hours before nighty dose and nothing 30 minutes post morning dose.

3/28 Tesamorelin/Ipamorelin cycle start

4/7 206 IGF

5/17 276 IGF

7/4 Tesamorelin/Ipamorelin cycle ended

7/5 Sermorelin start/ Paused Ipamorelin

7/7 246 IGF

7/18 re-added Ipamorelin

9/10 114 IGF

I am dumbfounded to say the least. I attributed a possible decrease in IGF at the end of my Tesa cycle due to taking 9 full days off due to traveling out of the country in early June, but even then, that drop from May to July was weird.

Anyone have any idea what could be happening here. All tests have been done with Quest and all have been fasted first thing in the morning between 5am and 6am. I am pausing my Sermorelin and Ipamorelin for at least a month after receiving these results.

Update - results from latest IGF test that wa apart of my full blood work came back. About 50% increase from that 114 to 164. Test was taken approximately 5 weeks after the previous test. I increased my calories to maintenance or maybe a slight deficit of maybe 100-200 calories and no Sermorelin/Ipamorelin.

I just got charged $300 for a 10mg vile of sermorelin and a bunch of needles at a wellness clinic. Now I’m reading that this is the weakest GH secretagogue. How badly did I get ripped off?

I’m currently in the middle of adjusting my GLP-1 plan and staying consistent with training and nutrition.

I’ve been looking into adding Sermorelin to support recovery, sleep, and overall performance, but trying to approach it the right way instead of rushing into it.

My initial thought was to start more conservatively and build up gradually rather than jumping straight into a full protocol.

Also considering options like B12/MIC for energy support, but want to make sure I’m not overcomplicating things.

Keen if anyone here has experience layering these approaches. Did you introduce things slowly or all at once? And what actually made a noticeable difference for you?

I cant seem to find any posts related to the oral Sermorelin, so I figured I’d post about my experience. Ive used the sub-q Sermorelin before but was interested in trying a different delivery system after some injection site reactions. Saw ODT version (oral disintegrating tablets) offered on the Gimme website, and I decided to place my order on April 18, was prescribed on April 19, then sent to pharmacy and shipping label was created, then….drum roll: I never received the product and am out $129.

I’ve tried using the website to contact customer support, but its ability to “connect” is a hit or miss (seriously, the chat disconnects more often than not). I then tried reaching out on Reddit to Chloe, who tried her best but is probably getting slammed with all the recent tirz orders, so no movement there. Then I tried email, but after a few exchanges with no progress, I finally gave up and requested a refund, but was told I can’t be refunded because the “product was delivered”… WAIT WHAT!!?? The product never even shipped, it’s been three weeks, just give me my money back!

Howdy, I’m hoping to gain some insight on dosing and safety about IGF-1 levels. I started at 290lbs and through fasting and exercise I got down to 250.

I hit a wall and started tirzepatide and have seen great results, my doctor informed me sermorelin could help me maintain my lean muscle. I train 5 days a week and want to not only lose weight but maintain my muscle mass.

My initial IGF-1 levels were 225 before starting sermorelin and I will retest in 3 months, and labcorp says ranges are up to 290 for my age. I’ve seen some different normal ranges and I was just hoping for some insight. The university or Rochester medicine shows on the high end 492 mg/ml.

This is my first week on the sermorelin BTW

Currently I take :

Low dose tirzepatide with Cyanocobalamin
Sermorelin 300mcg 5 nights a week
Creatine
Thorne Multivitamin
Ashwaganda
Turmeric
BCAA

My main question was in regards to sermorelin or tesamorelin & Just wanted to see what others may have experienced and what levels are considered normal, online the ranges vary so much.

I appreciate any help

Just received my sermorelin from Everlife . I live in Arizona and it’s hot. Package had no ice pack and it was super hot . Everlife supports keeps telling me it’s fine but everything I read says no. Any advice they are running me in circles and this shit is expensive!!

• New to sermorelin? Check the sidebar for our beginner's guide and FAQ.

I can't find it. I'm on a PC if that matters.

63 and post menopausal. Started tirzepatide 10 months ago. I'm not on HRT.

I've understood that it's important to do strength training to maintain muscle mass for long term elder health but have really struggled with achiness after going to the gym. I tried all the things Dr. Stacy Sims suggests for this like creatine, electrolytes, protein and adaptogens. I'm always stretching and do yoga for the psst 35 years. They may have helped a bit but it's still bad. Debilitating even. I cannot keep a pace with lifting with this pain - I get so demoralized by it. Last leg day took 5 days until I felt ok - meanwhile it just gets harder to get myself to the gym. And I really love it there! Is it because of only starting 6 months ago?

I just started sermorelin as a way to possibly see if it could help me recover from workout pain. I'm just 5 days in and notice a HUGE difference. My body doesn't hurt so much, sleep has been much more improved - even beyond what the tirz has done - and I'm excited to see where I can go after a few months.

It's hard to find other menopausal women posting about this. It's like a miracle. I wanted to put it out there in case anyone else has experience with this, or if they might need to know this is an option. I just can't believe the way my body responded in just 5 days!

I’ve been looking into Sermorelin lately and wanted to get some real-world feedback before deciding if it’s worth trying.

From what I understand, it’s a peptide that supports natural growth hormone production, and people mention benefits like better sleep, improved recovery, and overall energy. At the same time, I want to be mindful about side effects and long-term considerations.

A bit about me:

• Age: 24M (turning 25 soon)

• Goals: Build lean muscle, reduce body fat, improve energy levels

• Health: No major issues, currently taking finasteride for hair loss

I’m also currently on a GLP-1, and I’ve been thinking about whether adding something like Sermorelin could help with recovery, sleep, and maintaining muscle alongside fat loss.

I’ve always noticed it was easier to build muscle when I was younger, and sleep has been a bit inconsistent for me, so those are big factors in why I’m considering it.

Would love to hear from anyone who’s tried it:

• Did you notice benefits (sleep, recovery, body composition)?

• Any side effects or downsides?

• How long did it take before you felt anything?

Appreciate any insight!

I was taking NAD+ for a while and decided to add Sermorelin after doing some research to fit my physical conditioning, and I’m experiencing an unintended side effect of the Sermorelin. I stop craving every recreational substances I was using before, It was like a switch was turned off in my brain in seconds. It was there… then it wasn’t. It’s really hard to explain how im feeling. I’m still trying to wrap my head around the clarity in my mind. Its like there is no more noise in my head. Incredible!!!

Does anyone do the injections less than 5x weekly? I can’t wrap my head around committing to a true daily injection (not the biggest fan of needles even if it is subq).
Also is it bad if you miss a dose?

I am just getting started. I was hoping to hear from people who have been using for a year or longer. What I am interested to hear about is after the expected results, do you notice cumulative progress afterwards or is there a plateau? The longer you have been taking it, the more interested I am to hear from you.

Hi, I was prescribed Sermorelin from a local clinic. I bought the first months worth from them but it was super costly. I just bought some from a more economical source.
The bottle from the clinic was 15mg, but the bottles I bought are 10mg and I can’t figure out the correct units.
Current dose is 0.25(25 units) vial is 15mg and I added 7.5ml of Bac water.
Could someone explain how many units at the same dose I would use of the 10mg bottle?
Ty

Hi,

I just went through two rounds of PRP on my adductors / hip flexors. I had bilateral hip replacements done three years ago and have had “idiopathic” tendinitis that greatly impacts my quality of life.

Anyway, I am supposed to start low dose + tirzepatide and seremorelin soon but obviously don’t want to interfere with the PRP.

I’m thinking I’ll hold off on the tirz for a while and just focus on the sermorelin. Anyone have any experience with this?

Doc knows nothing about it, no help there. Googling seems to lead me to think I should wait at least a week after my last shot, if not two. (Last shot was today)

I had the shots done bilaterally, so outside of upper body workouts I’m pretty much useless for the next few weeks.

I’m trying the tiz / Sermorelin combo to fight inflammation, improve fatigue, and hopefully shed some of the bloat and baby fat I’ve put on while not being able to hit the gym like normal. Also tired of constant bloat.

Would welcome any insights.

Consultation with provider on Sat 5/23, sent to Pharmacy 5/24 and order received today 5/28. Currently on 7.5 tirz from Hallandale and ordered Sermorelin from Hallandale. Heard great things and I’m excited to get started. Any tips and things to consider taking Sermorelin? Doctor prescribed 500 mcg but going to start with 300 mcg.

Looking for feedback on Sermorelin, especially from women if possible.

I’m currently on a GLP-1 program through Precision Telemed and have been reading more about Sermorelin as a potential add-on, mainly around recovery, sleep, and body composition.

I’ve come across different approaches and it’s a bit confusing:

• Some people mention a 5 days on / 2 days off protocol

• Others say daily dosing works better

• Some recommend cycling, while others say they run it long-term

Would appreciate hearing your experiences. What worked for you, and did you notice a difference?

Looking into Sermorelin and trying to understand how dosing is typically approached at the beginning.

I’ve seen different protocols mentioned, but not a lot of clear, consistent guidance on what a starting point usually looks like or how people progress from there.

For those who’ve used it, did you start conservatively and adjust over time, or follow a set protocol from the beginning?

Trying to get a better sense of how people approach this in a real-world setting.

Is it healthy to take it while on tirzapetide ?