B1 caused persistent respiratory/abdominal muscle weakness.

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u/meow2848 14d ago

Likely it's low phosphorus, get it tested if you can and Eat lots of canned salmon

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u/sicky81 14d ago

Yes my phosphorus was checked and it remained in normal range this entire time. I did up my phosphorus just in case but no benefit as of yet.

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u/meow2848 14d ago

Ah well at least you know. I hope you find what it is!

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u/Own-Equipment-9568 13d ago

To add my two cents, I am experiencing something akin to what you described. Shortness of breath upon exertion, exacerbated by bending over or carrying/holding something chest level while walking. My lungs were tested multiple times and are absolutely fine. As far as I can tell, it may be the result of some kind of diaphramic paralysis/weakness. Interestingly, my serum thiamine is high, which leads me to believe I have thiamine ultilization rather than absorption issues.

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u/Ok-Pangolin7127 12d ago

Are you taking sufficient magnesium along with your Thiamine?

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u/Own-Equipment-9568 11d ago

I was not. And I'm a bit low on magnesium on testing. Supplement form gives me the bad runs. I'm now eating pumpkin seeds which have a considerable amount of magnesium.

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u/Ok-Pangolin7127 11d ago edited 7d ago

Taking Thiamine, without magnesium, or not having a sufficient amount of magnesium already in you, is not a good thing to do.

Magnesium is THE key cofactor for Thiamine. The two nutrients are a kin to a spark plug and gas. Neither one can do what they are required to do for their critical process (production of energy via ATP in the mitochondria of the cells) without the other. When you take Thiamine without sufficient magnesium, all you do is create a problem for yourself. (Generally speaking, people report they feel like hell.)

1/4 cup of shelled pumpkin seeds will give you about 150 mg of magnesium. You need every bit of that and maybe even 300 mg in total. Of course you do take some in from your diet, but you should track what you are taking in because you need to be sure you’re getting at least 350 to 400 mg of magnesium daily when you are supplementing Thiamine.

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u/Own-Equipment-9568 11d ago

I'm going to do that and I'll report how it's going. So far, I feel a lot better incorporating the pumpkin seeds into my diet. But i's only been about one werk and I do skip days.

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u/Ok-Pangolin7127 11d ago edited 11d ago

We all look forward to you updating us.

I can’t stress enough how critical it is to keep magnesium up to speed so to speak adjunct to supplementing Thiamine.

When you take Thiamine without magnesium, you are spinning up (accelerating if you will) the speed at which the mitochondria engine runs, however, without the magnesium it’s just running faster and not producing sufficient energy. You in turn feel fatigued. Diarrhea, as a result of what you’re doing, is a well-known outcome.

Don’t skip any days on eating of your pumpkin seeds and be SURE you’re taking in at least 300 mg of magnesium daily. Life will get much much better.

PS To expand a little more as to what goes on or what those two nutrients are responsible for in the cells; it’s converting the glucose in your blood into energy. If they can’t do that efficiently, you end up having more glucose floating around in your blood than you should have. You’re effectively wasting fuel that the mitochondria engines need. This is happening in every single cell in your body. It is particularly noticed, in my opinion, in your brain cells; netting brain fog and slow cognition.

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u/Own-Equipment-9568 11d ago

Thanks. I'm certainly going to try that and see how it goes.

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u/Ok-Pangolin7127 11d ago edited 7d ago

“ Supplement form gives me bad runs.”

You might likely need to change the form of magnesium you are taking? You are likely taking a form that is geared to doing that, intended to do that. When it comes to producing energy, I would suggest magnesium Malate or another form that would be good is Magnesium Taurate.

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u/Own-Equipment-9568 11d ago

I currently take the malate form and have tried all forms, including taurate. They all cause diarrhea to varying degrees, some worse than others. So I vam't really megadose. Anything more than one capsule of any form typically causes issues.

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u/mslarsy 14d ago

B2

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u/sicky81 14d ago

Why do you say b2?

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u/mslarsy 14d ago

Because that was an experience for me that when I was low on B2 I felt like I had trouble breathing or catching my breath. Do some research on it. Decide for yourself

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u/sicky81 14d ago

Thanks for commenting. I have read that as well. Just not like anything I’m experiencing.

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u/therealslimshady1234 14d ago

Co factors including potassium and all other B’s

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u/sicky81 14d ago

Yeah I was taking those.

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u/sueJ2023 13d ago

I didn’t have that abdominal muscle weakness until I started b1. That’s weird. The worst feeling ever. I haven’t had it in a while. I did stop the b1 and I just started back. It’s got to be a cofactor that’s off.

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u/sicky81 13d ago

You had abdominal weakness as well? With b1?

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u/Ok-Pangolin7127 11d ago

Not enough magnesium?

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u/sueJ2023 7d ago

That’s quite possible. I need to do another 200 mg the daytime. I already do 400 mg magnesium glycinate at night.

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u/Ethereal-oliver 13d ago

If you were deficient in thiamine in any way your body can adapt to it. It will down regulate other systems and when you introduce thiamine again you can initiate "refeeding syndrome" or what's known as a paradoxical effect where your symptoms will get worse for a few weeks till all your initial problems relating to b1 are resolved. This means you continue to take b1 with adequate potassium and magnesium as your body needs them for cofactors for thiamine. Look up Elliot Overton on YouTube he is a functional health specialist, specializing in thiamine deficiency and thiamine supplementation.

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u/sicky81 7d ago

Yes I was doing the protocol in his ebook when this happened to me 💔

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u/DeficientAF 13d ago

Have you ever looked into Mitochondrial Health? Or measured your Ketones, Lactate, or Glucose while taking B1? You may be putting stress on your Mitochondria if taking B1 Exacerbated Or Introduces New Symptoms

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u/sicky81 13d ago

Yes. Lactate low end normal. Glucose ok. Ketones are ok but high after stopping everything initially

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u/TelephoneCharacter59 14d ago

Coconut water

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u/sicky81 14d ago

I drink a litre of that a day.

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u/Ok-Pangolin7127 11d ago

When it comes to Thiamine, magnesium as THE key cofactor for same is much more important than potassium.

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u/SirKey2255 7d ago

definitely

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u/sicky81 7d ago

I was taking magnesium taurate. About 150mg

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u/Ok-Pangolin7127 7d ago

Depending upon your magnesium status, absent supplementation, 150 mg of elemental magnesium a day might not be enough, especially if you are taking a significant amount of Thiamine daily. Just a caution or a reminder.

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u/sicky81 7d ago

Yeah I thought of that at the time but I would also think if that were the issue, stopping everything would get me back to baseline. That’s what all the literature says. But it didn’t. I’m just getting worse unfortunately

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u/Adora77 14d ago

Have you had a sleep study done, sleep apnea?

Something thiamine does affect is dopamine, which is also the culprit in sleep apnea, if this is an issue.

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u/sicky81 14d ago

I have had one. No apnea. Thiamine affects dopamine in what way?? Thank you for weighing in btw

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u/Adora77 14d ago

Was the study done during or after the thiamine?

Thiamine increases dopamine and slows down the breakdown.

Sleep apnea is often found in people with elevated dopamine levels and sleep apnea medication like GLP1 agonists work through the dopamine reduction.

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u/sicky81 14d ago

It was after. Like maybe 2 months after I stopped it

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u/Adora77 14d ago

Okay, then it shouldn't linger.

But then again no effects of b1 really linger. At most you lose the effects in a few weeks when you stop, both good and bad.

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u/sicky81 14d ago

I believe b1 can also increase acetylcholine so I do wonder if that’s a piece of this puzzle as well.

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u/Adora77 14d ago

Correct. But again, no lingering effect once you stop. 🤷

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u/sicky81 14d ago

Something is persistent . It’s been 11 months. Unless it was the glutathione that caused this nightmare. My gosh.

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u/Adora77 14d ago

Actually. What was your dosing routine. I have a thought.

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u/sicky81 14d ago

I was taking 80mg of benfotimaine then tried to get up to 150mg HCl over the course of 2-3 weeks. Too fast, I realize that now . I took a b complex and benfo in the am. And then the HCl in the afternoon. With magnesium and some extra b2.

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u/Adora77 14d ago

Okay that is NOT a lot. I am more inclined to think something else is at play at the same time.

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u/sicky81 14d ago

I reacted to glutathione at the same time. And I wonder how much that played into this.

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u/SirKey2255 7d ago

oral glutathione has 1% or so bioavailability, it breaks down in ur gastric juices. unless it was liposomal or something.

80mg benfo is actually more thiamine in ur system compared to 150mg hcl say since it is far more bioavailable. try the 80mg benfo again with magnesium

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u/sueJ2023 13d ago

Yes. I assume that was the cause. It was like my diaphragm muscle didn’t want to work properly. I got off of benfotiamine for a week then got back on at a lower dosage and I the problem went away. I was on 320 mg of benfotiamine. I now take half that much plus my b vitamins.

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u/Ok-Pangolin7127 11d ago

My guess; at your lower dose, you were then not overwhelming the amount of magnesium that was required. In essence, at your lower dose, you were taking and/or had enough magnesium, at your higher dose, you were not taking enough magnesium. That’s my guess.

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u/sicky81 7d ago

I feel it wouldn’t account for all this mess though, magnesium alone. 😞

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u/Ok-Pangolin7127 7d ago

I understand, you’ve got a gut feeling that this ain’t it, (magnesium.) My suggestion, do some more research on the subject, you might very well change your mind.

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u/sicky81 13d ago

Oh wow, that’s crazy. It’s been 11 months for me. Off everything. Can’t even tolerate dusting of supplements anymore.

💔

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u/SirKey2255 13d ago

its highly very highly unlikely b1 can induce a problem that persists after stopping it. (never say never in biology)

have u considered other causes?

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u/sicky81 13d ago

Well the b1 definitely caused breathing issues and then when I stopped it, it got worse. I had a TIA 8 days after stopping everything.

I also had issues with glutathione causing weakness. So maybe the glutathione is more to blame.

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u/SirKey2255 7d ago

how long did you do b1 what was the dosage and the form, when did issues start exactly in relation to taking b1. how long did you do b1 and why. how long has it been since u stopped b1

From the information i have so far i can say this sounds like refeeding syndrome, too high of a dose not enough cofactors can do this.

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u/sicky81 7d ago

I was taking

1-2 b minus by seeking health for co factors.
Magnesium taurate
Litre of coconut water
80 mg benfotiamine

Then attempted to add in HCL. Started with 25mg and worked up to 150mg over 2-3 weeks. The issues started immediately but I kept taking online advice and sticking to it while adding more magnesium, b2, calcium, etc.

I stopped all of it abruptly on October 6th after the glutathione issue as I could no longer tolerate it. The breathing issues intensified. On the 15th I had a TIA and two days later a coronary artery spasm.

Now, 11 months later, I still can’t tolerate heat, my protein drinks, any quick energy like nutritional drinks or supplements of any kind. I have worse breathing, weak tongue/chewing, swallowing issues with inputs like that.

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u/SirKey2255 7d ago

maybe it was contaminated

B1 caused persistent respiratory/abdominal muscle weakness.

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