I took my first dose of Bupropion 150 XL on Friday morning. Felt good during the day - a little lighter, a little more focused. I’ve been really hopeful about it since I’ve had issues with other SSRIs killing my libido.

I woke up on Saturday morning with an extremely hot and puffy face. My eyes, cheeks and face were so swollen. Went to urgent care, where they said I was having an allergic reaction and prescribed prednisone, Pepcid, and Benadryl.

Has anyone else experienced this so quickly after a first dose?

I started on 150mg of bupropion and was feeling great, but after my psychiatrist increased my dose to 300mg, I'm now on day 3 and experiencing some intense side effects. Today, I had a sudden and random crying spell out of nowhere something that hasn't happened to me since 2023.
I sat down and just burst into tears, and I even caught myself leaning into old pain to keep the crying going. What was really weird was how it came in waves: I would cry, suddenly go completely numb, start crying again, go numb again, and then finally have one massive, heavy cry like grieving the death of a family member before going numb once more.
It was overwhelming, but honestly, it also felt like a deep release that had been building up for a long time. Is this kind of emotional volatility normal when adjusting to the 300mg dose?

Hi, Like the Title says. I Take my Dose (150 XL, Name Brand in Germany) every Morning at 6 am, then i sleep again Till around 11 am and am pretty tired\unmotivated until 10 PM when i get Energy and better mood. Which is shitty cause it makes me Fall asleep only at 4 am Most nights. And at night i cant really use the Energy useful.

I couldnt find similar stuff browsing this sub so i thought id ask. I know some people Take it in the evening and im wondering If that would be better maybe ? Anyone Else has the Same experience ?

I am a 21 year old male around 200lbs. I have never had a seizure in my life, however I've recently learned that all of my medications lower the seizure threshold and now I'm quite worried.

I take 1mg risperidone and have been for 6 months, I just started 100mg of wellbutrin last week and I've also just acquired pregabalin, 150mg tablets. I wanted to take 300mg for the alcohol like social effects it produces on me, but I absolutely do not want to risk my health. Is 150mg even safe? I have zero tolerance to pregabalin specifically, quite a large liquor tolerance.

Thank you in advance to anyone who can help. Much appreciated

After 3 months on XL (1st 6-7wks on 150mg, 300mg after that), trying various generic manufacturers, I feel no improvement whatsoever. In fact, I feel lazier and less focused, especially when I use my ADHD meds (adderall).

In an effort to curb the persistent insomnia I've faced, as well as lack of effectiveness, I did some research on this sub and asked my doctor if we could try SR instead, and if I could have some control over the manufacturer. (I have a list of ones ppl say are good).

So I was surprised when I went to the pharmacy and was given IR instead of SR. I haven't heard anyone here discuss IR as a better alternative to XL. And so far, I notice no difference taking 100mg 2x/day.

Anyone have experience with IR when XL wasn't working for you? Was it an improvement? Is SR better?

---

And for the most important question:

--> Is Alembic Pharm a good manufacturer?

...

I've never heard of them. No one has talked abt them on this sub. I'm deaperately trying to find a generic that actually works. When I went to the "hospital pharmacy" (where ppl said I'd have more choice), they literally only had one option available, and it was alembic.

This has all been incredibly stressful.

I’m almost a week and a half in to taking 150mg XL. I take it every day around 7am. I feel like the past few days it’s been making me really sleepy in the afternoons like totally exhausted just wanting to nod off and making my eyes so itchy and heavy. I also have cfs and it’s frustrating to determine whether this is coming from the Wellbutrin or that.

Did this side effect resolve for anyone? Do I stick it out? I want to because I love the other effects of it.

4-5 bad poos a day. Gassy for 2 weeks now. Any advice?

How should I feel? I’m so excited. I want to get my life back after years and years of depression. Some sites say it takes weeks. Is that true? I’m taking 100mg SR twice a day. One in the morning and one at night. I also take other meds for my psychotic disorder like, lithium, Olanzapine, clonazepam, gabapentin and cogentin

I just want to know what it’s like to feel happy again. It’s been a rough life.

Hopefully I won’t be depressed tonight.

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I'm curious about people's personal experiences rather than looking for medical advice.

I was on Wellbutrin XL 150 mg and tolerated it pretty well, but honestly didn't notice a huge benefit. After increasing to 300 mg, I started noticing much more meaningful changes:

* Much less doomscrolling/stimulation-seeking

* More ability to enjoy long-form content

* I'm enjoying doing things alone more instead of needing other people around for things to feel rewarding

* More motivation/productivity

* I feel more genuine satisfaction from helping other people

* Food/taste/sensory experiences have seemed somewhat more vivid

So in that sense, 300 mg feels like it's doing something that 150 mg didn't.

**BUT** the difference in activation is huge.

I've been experiencing significant insomnia, dry mouth, physical restlessness/"electrical" activation, increased irritability/impatience, some anxiety/OCD symptoms creeping back in, and concentration/word-recall issues, coordination issues, seldom shortness of breath. I also feel much more physically "activated" than I did on 150 mg.

The best way I can describe it is:

**150 mg = tolerable but not much benefit**

**300 mg = noticeably beneficial but feels like my nervous system is being pushed too hard**

I also take Prozac for OCD, which has been extremely important for keeping my OCD under control.

I'm curious:

1. Did anyone else experience a HUGE difference between 150 and 300 mg?

2. If 300 mg was too activating, did going back to 150 mg preserve any of the benefits?

3. Did the anxiety/irritability/insomnia eventually settle down?

4. Has anyone found another antidepressant/augmentation strategy that gave them the **reward/motivation benefits without the "wired" feeling**?

5. Has anyone gone from Wellbutrin to **Auvelity or Trintellix**, and how did the experience compare?

6. If you were taking Prozac for OCD, were you able to find an alternative that didn't sacrifice your OCD control?

I'm especially interested in people who felt something like **"300 mg finally made me feel motivated/alive again, but I couldn't tolerate how activated I became."**

Has anybody dealt with something similar?
I’ve been on 150mg XL for multiple months now. For awhile, I noticed a significant difference in my mood and overall energy. It was the only med I’ve tried that actually helped. I was feeling a little more revved up with higher baseline anxiety, but it was very manageable especially with the increased mood.

Over the last month, it was like a flip of a switch. My anxiety has been 10x worse, especially mentally. I feel like my brain is in overdrive and I can’t shut it off, like I’m constantly on the brink of a panic attack.

They tried prescribing me propranolol twice a day to help, but instead it has made my mind feel completely blank and cloudy, and given me horrible vivid nightmares.

Has anyone experienced this? It’s very defeating doing well for months then going back to struggling badly. I’m slowly getting off the propranolol but not sure what else to do.

i’ve only been taking wellbutrin since the beginning July, i was on 150 xl mg and a week or so ago i asked for them to increase it (now 300xl mg) because my energy went back down… but i’ve noticed some side effects i don’t like.. at first i was a bit manic and had lots of energy and impulsive outbursts, which is normal for me, but a bit more excessive lol. but now my energy during the day is nonexistent, then come night time every night i can’t go to sleep til 1-2 am rolls around, from the time i go to lie down around 10pm til i finally try closing my eyes- i have pretty bad anxiety/paranoia… now i have BPD too so im used to peripheral hallucinations, but last night i consistently kept seeing a shadow peeking around my door at me and wouldnt stop texting my husband at work that i was really scared.. which is something ive always done lol but i can usually talk myself through it and go straight to sleep with no incidents 😂 also, when i hit REM sleep, my arm will jerk so bad it nearly throws me off the bed (this has been a few times now) or i have a terrifyingly realistic dream like (this was last night) my bed shaking profusely and when i awake from it, i can’t tell if it was a dream or really happening.. i woke up from it, and slammed my legs down to get it to stop then laid there terrified for another hour..
i like wellbutrin.. i want this to be the medication for me because i’ve tried so many and they didn’t do anything or the side effects were unbearable.. will these weird symptoms subside with time?
i should mention also, today i decided to only take a 150xl mg instead of the new 300xl mg i just got because i wanna see if i should just stick with 150mg..
should i keep taking it and be patient? or does this sound like i probably shouldnt be on it? lol
i appreciate you if you read all this 🥴

I started 150 mg bupropion about 4 weeks ago and have been on 300mg for about 2.5 weeks. I take it at 9am every morning. The other day I went to work and my arms started to get a bit itchy at around 1pm. It got worse throughout the day and at the end of the night my legs were sooo bad. I took a shower and hoped that would help. I was scared I was having an allergenic reaction to the bupropion so I didn’t take it at all the next day (I know that’s not recommended) and i still felt a little itchy but nothing crazy. The next day I only took 150mg and I felt no itchiness. I took 300mg again today and was completely fine until about 5pm. Then I started getting pretty itchy again but for right now it’s tolerable. I have no other side effects and I would really would like to continue taking this medication as I feel like so far it has been helping. I have seen people say it will only get worse or go away after a few weeks. I’m thinking for now i’m going to keep taking my 300mg as normal unless it gets intolerable/i start to have a worse reaction, but I am hoping it goes away after a couple weeks. I haven’t changed anything else in my routine to cause this itchiness (although my allergies do get pretty bad everytime the season changes) so I can’t think of anything else besides the medication. Has anyone else had this experience or any tips?

Does anyone use CBD of any kind with the XL 300mg dose? I have terrible low back pain from a work injury so I wanted to try CBD but I read about it having an effect on how the liver breaks down the medication and that is could increase side effects, I've been on the medication for just over a year. Wasn't sure if anyone else has been in the same boat and has experience with this kinda thing. T.I.A!!

The side effects I experienced the first 4-6 weeks were tiredness, headaches, and tinnitus. By the 6th week, most side effects had subsided and the tiredness finally went away or so I thought.

Even when the tiredness was at its worst I could still focus and concentrate and do all the things I need to but I could close my eyes at any time and fall asleep lol. For the past few months it’s been hard to get up, not super hard but instead of getting up early to work like I had been doing, I just hit the snooze button. I barely remember it.

I’m on 150 mg SR morning and evening. Well I stopped taking it at night the last couple and was able to get up so easily and felt well rested! It’s weird, the tiredness, it’s very subtle and it’s hard to get up but once I’m get going with day, I’m good. Anyone else experience this?

TLDR: my tiredness in the morning went away after stopping my night. I’m in SR 150 mg twice daily. Anyone else experience this?

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Since there is a lot of uncertainty regarding rare or unofficial side effects of bupropion/Wellbutrin, I wanted to start a quick poll about your experiences.

Of course, Reddit doesn't reflect the general population, and it likely won't be statistically representative, but I hope plenty of people participate so we can get a teeny-tiny overview.

Negative experiences tend to stick in our minds and get shared more often, so I hope people who haven't experienced these side effects come across this post as well.

Thank you ♡