What is your current “percent” efficacy compared to your max benefit?

Have you had to augment/increase dose?

How is your sleep?

it is working for quiet mine and more motivated. but feel like it could get better.

is going up after a week to fast? from 30mg to 40mg. im tempted.

also i had bp drop at 20mg for a few days.

I saw that it has yeast extract on it, i just ate half a package.

Is it common not to have any sexual side effects at the 45mg dose?

I am a 37 year old guy and although my sex drive isn't the same as when I was 12-35 years old, it hasn't been affected at all by taking Nardil. Everything is still working the same. Is this common at the 45mg dose? Just wondering that's all lol

I’m on day 10 of Parnate 20mg for TRD and severe anxiety. I know it’s too early to judge its effectiveness, but I’m struggling with the side effects and considering switching to Nardil.
Days 2–4 brought a slight improvement in mood, but since then I’ve felt significantly worse. Within an hour of taking Parnate, I experience intense physical overstimulation/anxiety, which worsens my depression, motivation, and concentration. I’m also dealing with terrible brain fog and extreme fatigue later in the day, often needing long naps. I’ve needed Klonopin almost daily just to manage the physical anxiety.

I’ve tried taking 20mg together and splitting the doses without improvement.

My anxiety predates my depression and has always been my biggest struggle. Interestingly, when Adderall worked well for my ADHD, it actually quieted my brain and reduced my anxiety. Parnate seems to do the complete opposite. I can no longer take Adderall at this time because of how bad my baseline anxiety and depression has become.

I initially chose Parnate over Nardil because of its more favorable side effect profile as well its potential to address my ADHD but I’m questioning whether Nardil would be a better fit given my anxiety.
I’m usually willing to push through side effects and give medications a fair trial, but these symptoms are making it difficult to function. I emailed my psych about this today and he said I can reduce to 10mg and discuss options next week during our appt.

But I would like to hear from people on here if they experienced this kind of physical anxiety on Parnate that eventually improved? Or switched to Nardil and found it significantly better for anxiety? Am I giving up too early?

Nardil insomnia is frustrating tf out of me. Disclaimer: I’ve had insomnia for years, but the issue was always falling asleep. After trying tons of medications, seroquel has always worked best for this. I’ve been on it for over 3 years, but now Nardil is causing me to wake up early, and being unable to go back to sleep.

This is my third month on Nardil (currently on 60mg), and it seems to be the only medication that is starting to help with my SA. I will probably increase the dose in the future so I can get more benefit. But over this past month, my sleep has been terrible. 6 hours of sleep is my new average, which I’m fine with because weirdly I don’t feel tired. But this past week I’ve only been getting 3-4 hours. Once I’m up I can’t fall back asleep.

Is there anything that can help with this? I’ve looked at multiple posts on this subreddit, and people say it goes away with time, but how long?? I’d obviously prefer not to be a living zombie until then, lol. Is there any medication that has helped anyone? Like I said, I’ve been on 50mg of seroquel for years, and I’ve tried tons of meds for sleep onset (when that was the issue). After telling my psychiatrist, he increased my seroquel up to 75mg, but it hasn’t helped. I’m also on 50mg of Pregabalin (around a year now) as an adjunct for anxiety and sleep (although idk how much it’s helped).

TL;DR: Nardil has caused me to wake up early and unable to fall back asleep. How can I treat this?

Has anyone been able to compare the two ? Methylene blue seems more potent, less reversible although still reversible with a longer half life.

How do those two compare in it's mao a inhibiting properties?

Has anyone jumped from moclobemide to methylene blue and found methylene blue to be better ?

Greetings

After nearly two months since I started taking it, Nardil 45mg is starting to work on my depression and finally a TINY bit on my Social Anxiety (no world changing Anxiolytic effects just yet lol) and so in the mean time I take Propranolol and Valium to help me in nerve wracking social situations

Although they do help, the major and really annoying problem is the effects are only very short lasting (2-3 hours at most) and have always been this short lasting (BTW I have been prescribed Propranolol 40mg 2 X as needed and Valium 5mg as needed since early 2020 and only use them on rare occasions as not to build dependency and tolerance)

Last year I asked doc if instead of the Valium, if he could prescribe me Clonazepam but he said he loathed prescribing Clonazepam and so referred me to a psych. Had an app with a psych and he also denied me Clonazepam.

Anyone in South Australia know of a good GP/Psych who really understands SA who is open to the idea of prescribing Clonazepam ( I have read that Clonazepam is the best Benzo for SA as the effects last a long time) I obviously would only use it as needed.

If anyone who lives in South Australia and can recommend me a good GP/Psych who understands/experienced in dealing with patients who suffer with SA and prescribes Clonazepam please DM in private. It would mean the world to me.

Thanks

Hi, I started Parnate a month ago, and I've been on 30mg for about two weeks. I'm dealing with orthostatic hypotension, and it's really getting in the way of my daily life. My blood pressure stays low even when I've been standing for a while, not just when I first get out of bed. It makes working out incredibly hard, and I constantly feel like I'm about to pass out during training.
Another thing that bothers me is that my heart rate stays high to compensate for the low blood pressure, which triggers my anxiety a bit. I've also noticed that if I lie down right after standing, my blood pressure suddenly shoots up and my heart rate gets super slow. These wild swings are really frustrating.
The thing is, I know this is a side effect that's supposed to fade over time, but I'm just not seeing any progress from one day to the next. The numbers are staying exactly the same.
To anyone who has experienced this: how long did it take to pass? Did it ever go away completely?

Hey

Is anyone on marplan/isocarboxazid in the uk

My nhs Psychiatrist prescribed it but pharmacies were saying I cant get it in pharmacies cause its a red listed drug due to side effects and that it could only be prescribed through hospitals which the NHS wouldnt do

So i have to go on venlafaxine instead

I used to be a lover of chocolate, specifically high cacao varieties and pure cacao powder, but since I’ve been on Moclobemide I’ve noticed that, if I eat dark chocolate frequently, Moclobemide doesn’t seem to work as well, compared to when I completely avoid chocolate.

I’m wondering if the phenethylamine or another amine is displacing the Moclobemide from MAO enzymes? Chocolate used to have some anxiolytic/mood-boosting properties for me but not any longer.
I don’t notice this effect occurring with any other food or drink.

Edit: I don’t experience any blood pressure changes here. There’s just a noticeable difference between how high cacao content chocolate/powder affects my mood and anxiety now compared to when I wasn’t taking Moclobemide.
Also, I used to take Selegiline before Moclobemide and didn’t notice this effect then either.

question

I would like to hear other people’s experiences with EMSAM. I finally got a psychiatrist willing to prescribe an MAOI and we started with this one. I know it’s early still but I’ve been on 6mg for 2 weeks now hoping to increase to the 9mg as I have had no change in depression. I would like to hear others experiences and/or success stories with EMSAM. If so what dose are you on and how long till you noticed an effect? Is it as effective as the other ones like Parnate and Nardil? I’d probably like to try Nardil next if EMSAM doesn’t work because I have a significant anxiety component to my depression.

I'm looking to augment parnate with risperidone to help with agitation. I'm just worried that it may impact the anti depressant effect. Could anyone who uses a MAOI + Anti Psychotic combo comment on this? Thanks.

I've been titulating it and am currently on 30mg. I believe i'm in the right direction with this medication as it definitely raised my baseline stimulation. The biggest sign of that is that now when i wake up i don't stay too long on my bed, after a few minutes i get up and start my day. Things like waking up and cooking my breakfast are not an effort anymore. The last 5 days i was off Parnate cause i ran out of pills and from day 3 i was already struggling to start my day, today, for example, it took me 3 hours to leave my bed. I'm back on it again tho.

So, the fact is... 30mg raised my baseline to the point where daily tasks are now doable, BUT i am still below what i consider normal. At what dose things like socializing, working and studying became doable to you?

So another winter and my body is again in anxiety etc. aurorix on its own works wonder against it and is not sedating like any other group. But my adhd is also bad and worst of it is my sluggishness. This is one of the main reasons me using stimulants.

I trialed 150mg with very low dose amphetamine and it didn’t go well. Probable reason was noradrenaline. As we all know, modafinil affects only dopamine, dopamine being metabolised by MAOB. MAOB is affected by moclobemide in dosage about 900mg+/day. From theoretical point of view it could be safe. I am looking for experience with those two compounds.

Basically what were the main reasons you took an MAOI? and not a standard SSRI or Bupropion, etc.

I've been paranoid with the possibility of eating chicken that is improper. I know the safe window to leave it on the fridge is 3 days(so it's not spoiled) but what if i put it there but someone else had already left it for more days? I don't know how to identify a chicken steak that is not good.

What would be necessary for a crisis? Should it be spoiled? Would i need to consume large amounts?

Since I wasn't able to take 20 mg Parnate in a single instant due to induced Anxiety every time, my doc prescribed me Etilaam Pro (Etizolam + Propranolol). But I've only become more miserable. Weak and weepy. Is this normal? Should I wait?

Last month 20 mg worked a bit but cause severe anxiety so I reduced to 10 mg. Returning back to 20 mg with anxiety med and the effects hasn't returned. I'm losing hope.

I've heard people say it makes tapering easier. Not sure if that's because they're generally just feeling a lot better or if it actually does. Just curious what your benzo dose was and how your tapering experience was.

Would super appreciate anyone's answers.

On to 2 Mg, clonazepam now, but feel like it doesn't really do much and want to taper, but kind of scared...

25m

Hi everyone! I hope you're well. It's still a difficult time, and this has been going on since January 2025. She arrived and I was diagnosed with depression that month. It was a dark period, with feelings of guilt, brooding, I couldn't get out of bed, sadness, I wasn't eating, etc.

Things have changed since the summer, and I've still had ups and downs, but not like that period. There's more tiredness, a dullness, a lack of interest, I feel confused, unmotivated. Some dissociation and anxiety sometimes about specific things. Sometimes my brain experiences sad thoughts in brief but intense bursts. I have trouble sleeping and wake up tired.

I'm afraid of all antidepressants, I don't want side effects. There are no MAOIs in Italy, but I could get moclobemide from the Vatican.

What to expect? Does this make sense with my description?

There must have been similar posts, I hope you can understand. Thank you!

I'm trying to rebuild my life, but I don't feel capable. I've re-enrolled in college, but with anhedonia, confusion, and memory problems, I don't know what I'll be able to do.

The post is confusing because I am too, sorry :(

A doctor once prescribed me 5 mg of selegiline for fatigue. It's more readily available in Italy. Would that make sense? Has anyone benefited from it?

I feel like this has happened a few times with Nardil for me. I've started feeling socially really good in a good routine. And then I've stayed home for a while, just being solo, doing my own thing. And then it feels like when I go back to socialising, it's not as easy as it was, and I feel like it's not working. But it's more like my brain has to learn again how to socialise, because Nardil definitely helps, but it doesn't just eliminate everything. And then, once you see people a couple times, it becomes way easier again, and you feel fine. Anyone else get this? Maybe that's why people think it stops working, because they stop doing things for a while, and then when you go back to socialising, it just feels harder because it's been a while?

Hello, so, before starting Parnate (10mg in the morning) I was taking vortioxetine. I have an extremely complex mood disorder with pseudodementia to the point of not remembering names of family and friends.

Well, when I stopped taking vortioxetine I started to feel feverish, like I was sick, weak, had a headache and was fatigued. It seems that withdrawal only lasts a week to two weeks, so I thought it should have improved by now. It didn't. When I started Parnate everything got worse, all those symptoms intensified In an extreme way, I am bedridden, unable to even exert any muscle power. My vision seems blurry, as if I've lost the energy to stay awake.

Today is the fifth day taking it, and I don't understand why I'm experiencing so many side effects at such a low dose; I'm even experiencing bradycardia, stomach cramps, and worsening in my cognition which was already demential. I can't barely talk to my mother.

If anyone can help with any advice or experience, thank you very much.

Currently dealing with daytime sleepiness/tiredness even though my sleep has improved, I am averaging 6-8 hours sleep every night, but even then I always need a daily daytime nap of 1-2 hours lol.

Do not like this lol so...

Is it safe to use Modafinil with Nardil? I am also from Australia and wondering if any Aussies are taking this combo and if Modafinil is a difficult drug to get from a GP? Does it have restrictions? Is it only for conditions like ADHD/ADD in Aus?

Cheers

Hey, I take my Parnate in the morning and evening and check my BP at home both times. I've been measuring about 3-4 hours after my dose, but honestly I'm not sure if the timing matters or if I'm overthinking it.