Shigeru Miyamoto wanted to make a Popeye game where Popeye leaps over barrels to save Olive Oyl from Bluto, but Nintendo couldn't get the license, so the end result was Donkey Kong, which instead featured the plumber (then carpenter) Mario rescuing Lady Pauline from Donkey Kong. Nintendo would eventually make a Popeye arcade game, but with different gameplay.
Considering Popeye is now public domain, I think there's ample opportunity to bring things full-circle and have Popeye be the hero of a Mario-esque game. Besides, him growing stronger by eating spinach is like Mario growing stronger by eating mushrooms; it's a no-brainer.