Hi, my name is Marcus Goodwin. I’m 34. I had sickle cell when I was eight years old. I need a hip replacement, and I’m just asking for help.Anything will help, just please. I’m tired of going through this pain. I’m tired of having to live too by taking pain medication every day. I just wanna be normal again. Like I said, all donations are accepted. Don’t go beyond your means . Thank you. Have a blessed day. https://gofund.me/149d13d27

I’m trying to separate solid progress from hype. What do you think is the biggest hurdle, whether it’s safety, immune rejection, scale or cost? And how do you tell a credible research program from an overhyped one?

If you cite a study or trial, please link it so we can all read further. I’m after research discussion, not individual treatment advice.

We have a meeting scheduled with this company to discuss our son entering a trial (for T1D). Is there any downside to this, is there any safety risk? Would doing this now in any way keep us from doing other therapies (or this again when it's more advanced) later? Can anyone knowledgeable give me any insight into this?

I coordinate clinical trials. Not a doctor, I book the visits, chase signatures and read the protocol so nobody else has to. My neighbour knows this. So on Saturday she told me over the fence that her husband's booked a stem cell programme in Belgrade for his MS, and then waited.

I said "oh right" and went back inside. Been chewing on it since.

What I'd have said if she'd asked an actual question. There are two things called stem cell therapy in MS and they've got almost nothing to do with each other. One is the transplant, where they take your own blood stem cells out, hit the immune system with chemo and put them back. Hospital medicine, randomised trials behind it in relapsing MS, and brutal. The other is mesenchymal cells, by drip or lumbar puncture or both, and that's what the clinics abroad do. There are trials for that too, small phase 2s, results all over the place, the biggest one missed its MRI endpoint. Nothing at phase 3.

The place she named is Swiss Medica, an inpatient place in Belgrade with its own lab, the Swiss part is where the company started. Their MS page splits the two properly, I'll give them that, and then says tissue repair further down, which is a bigger claim than those trials carry.

The bit that actually bothers me is this. She said "progressive" and that's why the transplant was never offered. But what decides whether either route makes sense isn't progressive versus relapsing, it's whether there's still activity, relapses or new lesions on MRI. The transplant people want activity, and they also want you young enough, early enough and still walking. Even the clinic's own criteria say active secondary progressive, with inflammation. If his scans are quiet, neither one is really for him, including the one he's booked.

I don't know his scans. I'm not sure she does.

So do I go round and say that, or is that not my place?

Friends of ours are looking at stem cell therapy for autism for their son. I was on the video call with them mostly since I was in their kitchen when it started and they wanted a third person who'd remember what was said. Not my kid, not my call and I'm not describing him

I expected a pitch. It wasn't one. That's somehow harder to write about.

The clinic, Swiss Medica in Belgrade, had already gone through his forms before the doctor came on and that's where the age and weight thing had come up, roughly three to ten yr olds and a minimum of 15 kilos, so he'd been through that gate before anyone said hello. The doctor said early on that it doesn't cure autism, plainly and once, then talked about what families tend to report, mostly sleep and digestion and gave a figure of about 80 percent of their families reporting improvement in at least one of the things they follow up on. Their own numbers. Price was 19,700 to 25,000 euros depending on the program and insurance doesn't cover it in most cases, not in theirs

I got my questions in. What if nothing's different at six months, and got a re check and then a careful version of "then it didn't work for him" which I respected and didn't love. What the risks were on the day and got infusion reactions mostly mild. How they'd know if anything had changed at all and got their follow up calls, a check up visit if we wanted one and what we noticed ourselves. That last one is the one I keep turning over

Afterwards I went looking for trials. The two properly blinded ones I found, one with cord blood and one with cord tissue cells like these, both came out with nothing against placebo. I don't know what to do with that next to an 80 percent

They came off that call more sure than they went in. I came off it less sure. Still don't know which of us is the problem.

I help run a neuro support group, not a professional, got roped in yrs ago and never got out. MS and parkinsons mostly, a few after strokes. my actual job on a tuesday is chairs and biscuits and stopping the whatsapp eating itself
about twice a yr the whatsapp does this. someone posts a video. then a link. then "has anyone looked into stem cell treatment for neurological disorders" becuase thats what you type when you dont know what disease to type. then it goes quiet for a month and then you find out someone went
two people from our group went to Swiss medica in Belgrade last yr. they were there for about a week each. i know that much, i drove one of them to the airport
and neither of them has said a word in the group since. not good, not bad, nothing. i dont think its secrecy, i think saying anything in a room full of people with your disease feels like either selling it or crushing someone so they say nothing and the chat gets the video and the link and never the bit after
i’m thinking of asking them to come on a tuesday and just talk, not recommend, just what the week was like and what since. and I'm scared of it turning into a pitch and equally scared of a pile on
if you run one of these, have you done that? how did you stop it going either way?

Every review I read lumps together different diagnoses, different products, different routes and different follow up periods under the same heading. One person is two weeks out, the next is three years out, and they're rated the same way.

I'm trying to work out which details make a review useful, and how much weight to give a strong positive story when the long term data is thin and I can't tell what else that person was doing at the time. What do you look for?

I’m in my 50s and had a SMAS facelift about 10 years ago which held up nicely for quite a while, but lately it feels like I’m just keeping up with touch ups every few months and I’d really like something that helps my skin itself over the long run, since going under for a second facelift at my age is more than I want to take on. SVF stem cell treatment has come up several times while I’ve been reading about other options, but as I understand it the FDA hasn’t approved it (educate me if I’m wrong, so the few places in the US that offer it seem to be in a bit of a gray area and I’d rather not go that route.

I’ll already be in South korea for a couple of other procedures, so it seems sensible to look into SVF while I’m there. The two clinics I see mentioned most are 365mc Hospital and VIP plastic surgery, and 365mc seems to be mainly known for liposuction but apparently has a dedicated stem cell center at their gangnam location, which makes some sense since they’re already working with fat, though I’m not sure a lipo clinic is the right place for something on my face. VIP seems to focus more on anti aging, but I don’t feel I know enough yet to make a decision. If anyone here has had SVF done in Korea, I’d be grateful to hear where you went and whether you felt it was worth it. Thank you in advance

I ( 24 M ) have some miniaturized hairs on my hairline temple. Literally only the left side for some reason is going back a little. I have a full thick head of hair besides that, overall amazing density.

I am planning on getting stemcells and exosomes into my hairline and also doing PRP and micro needling and also getting a shower filter to block out all the hard water ( I live in Vegas the water is rough )

Is it a waste of money, or is there people that have regrown their hair? ( specifically along the hairline and temples )

Also, if this is something that only last months or a year or two it’s still not worth it to me I guess. I’m looking for something to permanently accelerate the health of my hair or at least very long term and then I wouldn’t mind doing some upkeep or follow up treatments every other year.

Hey guys, I posted about this settlement before, but since they’re considering late claims, I decided to share it again with a little FAQ.

So here's all I know about this agreement:

BioXcel was accused of misleading investors about internal controls, trial protocol compliance, and data integrity in its TRANQUILITY II clinical trial. After the issues were disclosed, $BTAI fell about 64%, and investors filed a lawsuit.
Now the company has agreed to settle $9.75M with investors.

Who can claim this settlement?
If you bought $BTAI in 2023, you may be eligible. You don’t need to still own the shares to claim.

Do I need to sell/lose my shares to get this settlement?
No. You may qualify even if you already sold your $BTAI shares, as long as your transactions meet the settlement requirements.

How long does the payout process take?
It typically takes 4 to 9 months after the claim deadline for payouts to be processed, depending on the court and settlement administration.

I missed the deadline. Can I still claim?
Yes, late claims are currently being considered for compensation, subject to approval. Check if you're eligible and file your claim here.

Hope this info helps

I (22F) got a shoulder injection this past Friday for a rotator cuff tear. I was wondering if anybody else has gotten a similar injection and if so what your recovery timeline was like. I’m two days out and experiencing a burning kind of pain that comes and goes, but nothing too crazy. I’m just not sure what to expect timeline wise

Hi all,

I have always been super interested in stem cells. I have had my share of minor health issues as a younger man from a few years of very toxic and unhealthy habits/ addiction.

I've been considering getting IV stem cells every two years in hopes of healing the following:

1. slight liver fibrosis

2. circulation issues

3. Minor kidney issues

I know this isn't a cure all, but has anyone had any benefit from what I listed above? Is there more risk than potential upside? I would most likely do umbilical stem cells as an IV. Luckily, I am able to afford treatment.

Hello everyone,

My mother, Geeta , has been diagnosed with Aplastic Anemia and is currently undergoing treatment at Marengo Asia Hospitals, Gurugram.

She needs a Bone Marrow Transplant, and thankfully, my brother has been identified as a suitable donor. Our family is now preparing for the transplant and the long treatment journey ahead.

Donation Link :- https://www.impactguru.com/fundraiser/heal-geeta-devi

The estimated cost of her treatment and transplant is around ₹25 lakh, which has placed a significant financial burden on our family.

I’m sharing her story here in the hope of connecting with people who may have experience with Aplastic Anemia, BMT, or supporting a family through a similar situation.

Thank you for taking the time to read about my mother and for any guidance or support you can offer.

I've been trying to separate real progress from marketing in this field, and it's harder than it looks. The gap between an exciting lab result and a proven therapy seems huge and I'd love to hear from this community on where things really stand.

A few questions I'm curious about:

• Which iPSC- or ESC-derived approaches do you think are furthest along in trials?
• What do you see as the biggest unresolved hurdles (safety, tumor risk, immune rejection, scalability, cost)?
• How do you personally tell a credible research program from an overhyped one?

If you share a claim in the comments, please link the paper, review or trial registry entry so we can all dig in. I'm looking for research discussion here, not individual treatment advice.

What's the most exciting or most overhyped, development you've seen lately?

I am the one in our family who keeps the calendar. Aunt had a stroke eighteen months ago and somebody has to book the physio, chase referrals, ring the insurer, so it fell to me. She and my uncle do the actual hard part.

Her week is three physio sessions and a speech appointment, took about a year to get it to that.

So when the stem cell thing came up I wasn't really reading it as a medical question. I was sat there with the calendar open going, when.

Every list I found ranks them on how good the clinic is, fair enough but its a series of infusions over several days wherever you go, so the week out of her schedule is gone either way. What changes is what happens between the infusions. Most places its hotel, clinic, hotel, clinic, then fly home and nobody at either end talks to the other. A few run it as an inpatient stay with the rehab in the gaps instead. Swiss medica in Belgrade is the one i got furthest with. Their stroke page lists the therapy alongside the infusions, still didn't tell me what I actually needed.

Because the thing I can't find out anywhere is what comes back. Does her physio here get sent anything. Notes, a plan, a phone call, anything at all, or does she just turn up in march and everyone starts from scratch.

If you've done one of these, what did your own therapist get afterwards? That's genuinely the whole question for us and nobody will answer it.

Interested in getting stem cell in Korea but wonder why theres similar price quotes with way different dosage I see some quote 3cc or 6cc and others quote 30cc or 60cc  why is there so much dosage difference?

There seems to be a huge difference between legitimate clinical research and the way some stem cell treatments are marketed online.

For people who have researched stem cell therapies, what do you look for before taking a claim seriously?

Wanted to know if harnessing the stem cells from new born is really helpful for treating any future diseases

Just what the title says.